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Viral programming of progenitor cell commitment

Human cytomegalovirus (HCMV) infects pluripotent haematopoietic progenitor cells, yet it is latent in monocyte/myeloid-lineage cells. A new study reveals that HCMV achieves this by actively reprogramming the infected progenitor cell into a unique monocyte subset, enabling the successful lifelong persistence of HCMV in its host.

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  • 08 June 2018

    In the version of this News & Views originally published, ref. 6 was incorrectly cited instead of ref. 5 at the end of the sentence shown below. This has now been corrected.

    “Indeed, a proof of concept study has shown that latently expressed US28 can be targeted using an immunotoxin-based approach to eliminate infected cells in vitro5.”


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Correspondence to Matthew B. Reeves.

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Fig. 1: Human cytomegalovirus and haematopoiesis.