ANTIMICROBIALS

Discovering antibiotics from the global microbiome

Metagenomic sequencing, bioinformatic analysis and heterologous expression of an orphan biosynthetic gene cluster widely found in the environment led to the discovery and structural characterization of a novel group of calcium-dependent antibiotics hidden in plain sight.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Sequence-guided characterization of the malacidins.

References

  1. 1.

    Allen, H. K. et al. Nat. Rev. Microbiol. 8, 251–259 (2010).

  2. 2.

    Hover, B. M. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0110-1 (2018).

  3. 3.

    Robbel, L. & Marahiel, M. A. J. Biol. Chem. 285, 27501–27508 (2010).

  4. 4.

    Schneider, T. et al. Antimicrob. Agents Chemother. 53, 1610–1618 (2009).

  5. 5.

    Ling, L. L. et al. Nature 517, 455–459 (2015).

  6. 6.

    Breukink, E. & de Kruijff, B. Nat. Rev. Drug Discov. 5, 321–332 (2006).

  7. 7.

    Walsh, C. T., Fisher, S. L., Park, I.-S., Prahalad, M. & Wu, Z. Chem. Biol. 3, 21–28 (1996).

  8. 8.

    Blin, K., Kim, H. U., Medema, M. H. & Weber, T. Brief Bioinform. https://doi.org/10.1093/bib/bbx146 (2017).

Download references

Author information

Correspondence to Jason M. Crawford.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Further reading