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ANTIMICROBIALS

Discovering antibiotics from the global microbiome

Nature Microbiology volume 3, pages 392–393 (2018)Cite this article

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Metagenomic sequencing, bioinformatic analysis and heterologous expression of an orphan biosynthetic gene cluster widely found in the environment led to the discovery and structural characterization of a novel group of calcium-dependent antibiotics hidden in plain sight.

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Fig. 1: Sequence-guided characterization of the malacidins.

References

  1. Allen, H. K. et al. Nat. Rev. Microbiol. 8, 251–259 (2010).

    Article  CAS  PubMed  Google Scholar 

  2. Hover, B. M. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0110-1 (2018).

    PubMed  Google Scholar 

  3. Robbel, L. & Marahiel, M. A. J. Biol. Chem. 285, 27501–27508 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Schneider, T. et al. Antimicrob. Agents Chemother. 53, 1610–1618 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ling, L. L. et al. Nature 517, 455–459 (2015).

    Article  CAS  PubMed  Google Scholar 

  6. Breukink, E. & de Kruijff, B. Nat. Rev. Drug Discov. 5, 321–332 (2006).

    Article  CAS  PubMed  Google Scholar 

  7. Walsh, C. T., Fisher, S. L., Park, I.-S., Prahalad, M. & Wu, Z. Chem. Biol. 3, 21–28 (1996).

    Article  CAS  PubMed  Google Scholar 

  8. Blin, K., Kim, H. U., Medema, M. H. & Weber, T. Brief Bioinform. https://doi.org/10.1093/bib/bbx146 (2017).

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Authors and Affiliations

  1. Department of Chemistry, Chemical Biology Institute, Yale University, New Haven, CT, USA

    Yick Chong Lam & Jason M. Crawford

  2. Department of Microbial Pathogenesis at the Yale School of Medicine, New Haven, CT, USA

    Jason M. Crawford

Authors
  1. Yick Chong Lam
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  2. Jason M. Crawford
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Correspondence to Jason M. Crawford.

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The authors declare no competing interests.

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Lam, Y.C., Crawford, J.M. Discovering antibiotics from the global microbiome. Nat Microbiol 3, 392–393 (2018). https://doi.org/10.1038/s41564-018-0135-5

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