APOBEC3G is an antiviral protein that has long been known to inhibit retrovirus replication by hypermutating viral DNA. An additional mechanism is now identified, in which APOBEC3G binds to the HIV-1 reverse transcriptase, inhibiting viral DNA synthesis.
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Bieniasz, P.D. A multimodal antiretroviral protein. Nat Microbiol 3, 122–123 (2018). https://doi.org/10.1038/s41564-017-0104-4
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DOI: https://doi.org/10.1038/s41564-017-0104-4
