SYNTHETIC BIOLOGY

Tackling host–circuit give and take

The incorporation of additional gene circuits into hosts can often lead to unpredicted and undesirable behaviours. Recent work has developed a modelling framework that accounts for host–circuit interactions and can predict a variety of phenotypes at both single-cell and population levels.

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Fig. 1: Incorporating synthetic circuits.

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Correspondence to Mark P. Brynildsen.

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Aedo, S.J., Gelderman, G. & Brynildsen, M.P. Tackling host–circuit give and take. Nat Microbiol 2, 1584–1585 (2017). https://doi.org/10.1038/s41564-017-0058-6

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