VIRUS PATHOGENESIS

Zika virus targets blood monocytes

Two studies identify circulating monocytes as the primary cellular target of Zika virus infection in human blood. Monocytes are an ideal target as they have the potential to be used as a Trojan horse to infiltrate immune-sheltered tissues, including placenta, testes and the brain, to spread Zika virus.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Zika virus infection of blood cells.

References

  1. 1.

    Cao-Lormeau, V. M. et al. Lancet 387, 1531–1539 (2016).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Brasil, P. et al. New Engl. J. Med. 375, 2321–2334 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Brooks, J. T. et al. MMWR 65, 745–747 (2016).

    PubMed  Google Scholar 

  4. 4.

    Foo, S. S. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-017-0016-3 (2017).

    Google Scholar 

  5. 5.

    Michlmayr, D., Andrade, P., Gonzalez, K., Balmaseda, A. & Harris, E. Nat. Microbiol. https://doi.org/10.1038/s41564-017-0035-0 (2017).

    PubMed  Google Scholar 

  6. 6.

    Shi, C. & Pamer, E. G. Nat. Rev. Immunol. 11, 762–774 (2011).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. 7.

    Yewdell, J. W. & Brooke, C. B. Cell Cycle 11, 1748–1749 (2012).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Mansuy, J. M. et al. Emerg. Infect. Dis. 23, 863–865 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  9. 9.

    Tang, W. W. et al. Cell Rep. 17, 3091–3098 (2016).

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Elong Ngono, A. et al. Cell Host Microbe 21, 35–46 (2017).

    CAS  Article  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Akiko Iwasaki.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Jurado, K.A., Iwasaki, A. Zika virus targets blood monocytes. Nat Microbiol 2, 1460–1461 (2017). https://doi.org/10.1038/s41564-017-0049-7

Download citation

Further reading