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ANTIMICROBIALS

Hitting malaria where it hurts

The goal of malaria eradication is threatened by drug resistance. Now, two studies characterize Plasmodium falciparum PKG inhibitors and hexahydroquinolines as antimalarial compounds that could block transmission and help mitigate the risk of parasite escape via drug resistance.

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Correspondence to Thierry Diagana.

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The authors are employees of Novartis.

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Fig. 1: P. falciparum PfMDR1 is an ABC transporter that has been linked to resistance against different antimalarials.