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Cancer immunotherapy

A mobile home for T cells

Nature Materials volume 23, pages 735–736 (2024)Cite this article

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Lyophilized lymph nodes are a natural scaffold to deliver chimeric antigen receptor (CAR) T cells to tumour resection sites, where they serve as a natural T cell-supporting niche and enhance CAR T cell efficacy in reducing recurrence in preclinical tumour resection models.

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Fig. 1: L-LNs for CAR T cell therapy against postoperative tumour recurrence.

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Authors and Affiliations

  1. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

    Kewen Lei & Darrell J. Irvine

  2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    Darrell J. Irvine

  3. Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    Darrell J. Irvine

  4. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA

    Darrell J. Irvine

  5. Howard Hughes Medical Institute, Chevy Chase, MD, USA

    Darrell J. Irvine

Authors
  1. Kewen Lei
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  2. Darrell J. Irvine
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Correspondence to Darrell J. Irvine.

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The authors declare no competing interests.

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Lei, K., Irvine, D.J. A mobile home for T cells. Nat. Mater. 23, 735–736 (2024). https://doi.org/10.1038/s41563-024-01906-z

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