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Cancer nanomedicine

Exploiting endothelial transcytosis to reach into the brain

Targeting P-selectin enables safer and more effective nanomedicine delivery through caveolin-1-mediated endothelial transcytosis in preclinical medulloblastoma tumour models.

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Fig. 1: Mechanism of nanoparticle transcytosis across the blood–brain barrier endothelium.


  1. Arvanitis, C. D., Ferraro, G. B. & Jain, R. K. Nat. Rev. Cancer 20, 26–41 (2020).

    Article  CAS  Google Scholar 

  2. Tylawsky, D. E. et al. Nat. Mater. (2023).

    Article  Google Scholar 

  3. Sheth, V., Wang, L., Bhattacharya, R., Mukherjee, P. & Wilhelm, S. Adv. Funct. Mater. 31, 2007363 (2021).

    Article  CAS  Google Scholar 

  4. Terstappen, G. C., Meyer, A. H., Bell, R. D. & Zhang, W. D. Nat. Rev. Drug Discov. 20, 362–383 (2021).

    Article  CAS  Google Scholar 

  5. Vestweber, D. & Blanks, J. E. Physiol. Rev. 79, 181–213 (1999).

    Article  CAS  Google Scholar 

  6. Hallahan, D. E., Staba-Hogan, M. J., Virudachalam, S. & Kolchinsky, A. Cancer Res. 58, 5216–5220 (1998).

    CAS  Google Scholar 

  7. Shamay, Y. et al. Sci. Transl. Med. 8, 345ra87 (2016).

    Article  Google Scholar 

  8. Donahue, N. D., Acar, H. & Wilhelm, S. Adv. Drug Del. Rev. 143, 68–96 (2019).

    Article  CAS  Google Scholar 

  9. Sindhwani, S. et al. Nat. Mater. 19, 566–575 (2020).

    Article  CAS  Google Scholar 

  10. Wilhelm, S. et al. Nat. Rev. Mater. 1, 16014 (2016).

    Article  CAS  Google Scholar 

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Correspondence to Stefan Wilhelm.

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Wang, L., Wilhelm, S. Exploiting endothelial transcytosis to reach into the brain. Nat. Mater. 22, 282–283 (2023).

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