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COLLECTIVE CELL MIGRATION

Steering from the rear

In the absence of biochemical gradients, cancer cell migration over fibrillar isotropic collagen can occur by a mechanical self-steering process involving asymmetric matrix deformation from the rear.

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Fig. 1: Asymmetry of structural and molecular signals involved in collective migration on viscoelastic collagen networks.

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Correspondence to Katarina Wolf or Peter Friedl.

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Wolf, K., Friedl, P. Steering from the rear. Nat. Mater. 21, 1104–1105 (2022). https://doi.org/10.1038/s41563-022-01357-4

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