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Steering from the rear

In the absence of biochemical gradients, cancer cell migration over fibrillar isotropic collagen can occur by a mechanical self-steering process involving asymmetric matrix deformation from the rear.

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Fig. 1: Asymmetry of structural and molecular signals involved in collective migration on viscoelastic collagen networks.


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Correspondence to Katarina Wolf or Peter Friedl.

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Wolf, K., Friedl, P. Steering from the rear. Nat. Mater. 21, 1104–1105 (2022).

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