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GENE EDITING

Overcoming delivery barriers with LNPs

Ionizable phospholipids have been developed to enhance the delivery of mRNA and sgRNA for gene editing by selective organ targeting and endosomal membrane destabilization.

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Fig. 1: iPhos lipid design directs LNP tissue targeting.

adapted with permission from ref. 6, Springer Nature Ltd.

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Correspondence to Steven F. Dowdy.

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S.F.D. is a member of the scientific advisory board of Generation Bio, a gene therapy biotechnology company.

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Jadhav, S.G., Dowdy, S.F. Overcoming delivery barriers with LNPs. Nat. Mater. 20, 575–577 (2021). https://doi.org/10.1038/s41563-021-00988-3

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