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Overcoming delivery barriers with LNPs

Ionizable phospholipids have been developed to enhance the delivery of mRNA and sgRNA for gene editing by selective organ targeting and endosomal membrane destabilization.

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Fig. 1: iPhos lipid design directs LNP tissue targeting.

adapted with permission from ref. 6, Springer Nature Ltd.


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Correspondence to Steven F. Dowdy.

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Competing interests

S.F.D. is a member of the scientific advisory board of Generation Bio, a gene therapy biotechnology company.

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Jadhav, S.G., Dowdy, S.F. Overcoming delivery barriers with LNPs. Nat. Mater. 20, 575–577 (2021).

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