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DNA NANOSTRUCTURES

Nanodevices for cancer vaccination

Nature Materials volume 20, pages 286–287 (2021)Cite this article

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An elaborate DNA origami tubular nanodevice encapsulating antigens and adjuvants protects mice from cancer through tumour-specific immunomodulation.

Vaccines train the immune system to precisely eliminate pathogens from harming the human body and so far they have saved numerous lives1. Cancer vaccines are designed to prevent and combat tumours by eliciting a tumour-specific humoral and cellular immunity2. To date there is a growing list of identified tumour-associated antigens and adjuvants, as well as increasing knowledge of cancer immunology, boosting the advances in the development of cancer vaccines3,4. Yet, the outcomes of both the prophylactic vaccines and the therapeutic vaccines in cancer management are unsatisfactory, partially due to the insufficient delivery of vaccine components and the failure of on-demand release2,5. In this issue of Nature Materials, Baoquan Ding and colleagues developed a cancer vaccine based on a DNA-based nanodevice that can be efficiently transported to draining lymph nodes (dLNs) and is capable of delivering tumour antigens to antigen-presenting cells (APCs) to stimulate an anti-tumour immune response6.

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Fig. 1: Subcutaneous administration of a tubular DNA origami nanodevice vaccine for robust antigen-specific immune response against tumours.

References

  1. Hollingsworth, R. E. & Jansen, K. NPJ Vaccines 4, 7 (2019).

    Article  Google Scholar 

  2. Van der Burg, S. H. et al. Nat. Rev. Cancer 16, 219–233 (2016).

    Article  Google Scholar 

  3. Smith, C. C. et al. Nat. Rev. Cancer 19, 465–478 (2019).

    Article  CAS  Google Scholar 

  4. Anguille, S. et al. Leukemia 26, 2186–2196 (2012).

    Article  CAS  Google Scholar 

  5. Kranz, L. M. et al. Nature 534, 396–401 (2016).

    Article  Google Scholar 

  6. Liu, S. et al. Nat. Mater. https://doi.org/10.1038/s41563-020-0793-6 (2020).

  7. Jiang, Q. et al. Adv. Mater. 31, e1804785 (2019).

    Article  Google Scholar 

  8. Wang, P. F. et al. Chem 2, 359–382 (2017).

    Article  CAS  Google Scholar 

  9. Lu, Y., Aimetti, A. A., Langer, R. & Gu, Z. Nat. Rev. Mater. 1, 16075 (2016).

    Article  Google Scholar 

  10. Ott, P. A. et al. Nature 547, 217–221 (2017).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China

    Hongjun Li & Zhen Gu

  2. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA

    Zhen Gu

Authors
  1. Hongjun Li
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  2. Zhen Gu
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Correspondence to Zhen Gu.

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The authors declare no competing interests.

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Li, H., Gu, Z. Nanodevices for cancer vaccination. Nat. Mater. 20, 286–287 (2021). https://doi.org/10.1038/s41563-021-00941-4

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  • DOI: https://doi.org/10.1038/s41563-021-00941-4

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