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DNA NANOSTRUCTURES

Nanodevices for cancer vaccination

Nature Materials volume 20, pages 286–287 (2021)Cite this article

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An elaborate DNA origami tubular nanodevice encapsulating antigens and adjuvants protects mice from cancer through tumour-specific immunomodulation.

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Fig. 1: Subcutaneous administration of a tubular DNA origami nanodevice vaccine for robust antigen-specific immune response against tumours.

References

  1. Hollingsworth, R. E. & Jansen, K. NPJ Vaccines 4, 7 (2019).

    Article  Google Scholar 

  2. Van der Burg, S. H. et al. Nat. Rev. Cancer 16, 219–233 (2016).

    Article  Google Scholar 

  3. Smith, C. C. et al. Nat. Rev. Cancer 19, 465–478 (2019).

    Article  CAS  Google Scholar 

  4. Anguille, S. et al. Leukemia 26, 2186–2196 (2012).

    Article  CAS  Google Scholar 

  5. Kranz, L. M. et al. Nature 534, 396–401 (2016).

    Article  Google Scholar 

  6. Liu, S. et al. Nat. Mater. https://doi.org/10.1038/s41563-020-0793-6 (2020).

  7. Jiang, Q. et al. Adv. Mater. 31, e1804785 (2019).

    Article  Google Scholar 

  8. Wang, P. F. et al. Chem 2, 359–382 (2017).

    Article  CAS  Google Scholar 

  9. Lu, Y., Aimetti, A. A., Langer, R. & Gu, Z. Nat. Rev. Mater. 1, 16075 (2016).

    Article  Google Scholar 

  10. Ott, P. A. et al. Nature 547, 217–221 (2017).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China

    Hongjun Li & Zhen Gu

  2. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA

    Zhen Gu

Authors
  1. Hongjun Li
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  2. Zhen Gu
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Correspondence to Zhen Gu.

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The authors declare no competing interests.

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Li, H., Gu, Z. Nanodevices for cancer vaccination. Nat. Mater. 20, 286–287 (2021). https://doi.org/10.1038/s41563-021-00941-4

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