Extended Data Fig. 8: Calibration of the organic neuromorphic device with increasing dopamine concentration. | Nature Materials

Extended Data Fig. 8: Calibration of the organic neuromorphic device with increasing dopamine concentration.

From: A biohybrid synapse with neurotransmitter-mediated plasticity

Extended Data Fig. 8

a, Pulsed measurements of the ex vivo neuromorphic device under microfluidic flow of DMEM solution at varied dopamine concentrations showing the postsynaptic conductance change following voltage pulses with increasing dopamine concentration. b, Calibration curve showing the conductance change during pulsing (left, dark blue) and peak transconductance during transfer measurements (right, light blue) as a function of increasing dopamine concentration. c, Postsynaptic channel conductance update as a function of gate voltage pulse width for the ex vivo neuromorphic device with varied dopamine concentrations showing a nearly linear time dependence for all concentrations. The minimum pulse width resulting in a change in postsynaptic current (LTP) also depends on the dopamine concentration; at 0.02 mM the pulse width must be >100 ms to elicit a response, whereas at 0.2 mM a pulse width of 10 ms is sufficient to cause LTP.

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