TUMORIGENIC REPROGRAMMING

Oncogenetic engagement with mechanosensing

Reprogramming normal cells into tumour precursors involves complex reconditioning of the tissue microenvironment. Cumulative integration of genetic drivers with extrinsic mechanical inputs is now shown to engage YAP/TAZ to rewire cell mechanics and initiate tumorigenic reprogramming.

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Fig. 1: Mechanical inputs and oncogenic activators forge YAP/TAZ- mediated tumorigenesis.

Change history

  • 02 July 2020

    In the PDF version of this News & Views originally published, Sayan Chakraborty’s ORCID was incorrectly listed as 0000-0003-3849-8038; it should have been 0000-0002-5591-8164. This has now been updated.

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Correspondence to Sayan Chakraborty or Wanjin Hong.

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Chakraborty, S., Hong, W. Oncogenetic engagement with mechanosensing. Nat. Mater. 19, 707–709 (2020). https://doi.org/10.1038/s41563-020-0700-1

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