While integrin-based adhesions are thought to underlie many aspects of cell response to localized tension, another matrix receptor, syndecan-4, has now been shown to act as a mechanosensor, which triggers cell-wide integrin activation and adhesion reinforcement.
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Guilluy, C., Dolega, M.E. Syndecan-4 forces integrins to cooperate. Nat. Mater. 19, 587–588 (2020). https://doi.org/10.1038/s41563-020-0689-5
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DOI: https://doi.org/10.1038/s41563-020-0689-5
