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Active transcytosis and new opportunities for cancer nanomedicine

New evidence suggests that the mechanism of nanoparticle entry into solid tumours may be driven by an active process. This insight paves the way for approaches to enhance the efficiency of nanomedicine delivery by harnessing active transport mechanisms, and encourage researchers to rethink how tumours are treated.

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Fig. 1: Active and passive mechanisms for in vivo nanoparticle delivery.

References

  1. Chan, W. C. W. Acc. Chem. Res. 50, 627–632 (2017).

    Article  CAS  Google Scholar 

  2. Nakamura, H., Jun, F. & Maeda, H. Expert Opin. Drug Deliv. 12, 53–64 (2015).

    Article  CAS  Google Scholar 

  3. Wilhelm, S. et al. Nat. Rev. Mater 1, 16014 (2016).

    Article  CAS  Google Scholar 

  4. Shi, J., Kantoff, P., Wooster, R. & Farokhzad, O. C. Nat. Rev. Cancer 17, 20–37 (2017).

    Article  CAS  Google Scholar 

  5. Sindhwani, S. et al. Nat. Mater. https://doi.org/10.1038/s41563-019-0566-2 (2020).

  6. Hobbs, S. K. et al. Proc. Natl Acad. Sci. USA 95, 4607–4612 (1998).

    Article  CAS  Google Scholar 

  7. Schnitzer, J. E. Am. J. Physiol. Heart Circ. Physiol. 262, H246–H254 (1992).

    Article  CAS  Google Scholar 

  8. Dvorak, H. F., Nagy, J. A., Dvorak, J. T. & Dvorak, A. M. Am. J. Pathol. 133, 95–109 (1988).

    CAS  Google Scholar 

  9. Oh, P. et al. Nat. Med. 20, 1062–1068 (2014).

    CAS  Google Scholar 

  10. Liu, Y. et al. Nano Lett. 19, 8010–8020 (2019).

    Article  CAS  Google Scholar 

  11. Detampel, P. et al. PloS ONE 14, e0223339 (2019).

    Article  CAS  Google Scholar 

  12. Ayloo, S. & Gu, C. Curr. Opinion Neurobiol. 57, 32–38 (2019).

    Article  CAS  Google Scholar 

  13. Wiley, D. T., Webster, P., Gale, A. & Davis, M. E. Proc. Natl Acad. Sci. USA 110, 8662–8667 (2013).

    Article  CAS  Google Scholar 

  14. Zhou, Q. et al. Nat. Nanotechnol. 14, 799–809 (2019).

    Article  CAS  Google Scholar 

  15. Ruan, G., Agrawal, A., Marcus, A. I. & Nie, S. J. Am. Chem. Soc. 129, 14759–14766 (2007).

    Article  CAS  Google Scholar 

  16. Ruoslahti, E. Adv. Drug Deliv. Rev. 110–111, 3–12 (2017).

    Article  Google Scholar 

  17. Schmid, D. et al. Nat. Commun. 8, 1747 (2017).

    Article  Google Scholar 

  18. Ledford, H. Nature 497, 544–544 (2013).

    CAS  Google Scholar 

  19. Syn, N. L., Teng, M. W. L., Mok, T. S. K. & Soo, R. A. Lancet Oncol. 18, e731–e741 (2017).

    Article  Google Scholar 

  20. Jiang, W. et al. Nat. Biomed. Eng. 1, 0029 (2017).

    Article  CAS  Google Scholar 

  21. Reinhard, K. et al. Science 367, 446–453 (2020).

    Article  CAS  Google Scholar 

  22. Sahin, U. et al. Nature 547, 222–226 (2017).

    Article  CAS  Google Scholar 

  23. Yuan, H. et al. Nat. Nanotechnol. 12, 763–769 (2017).

    Article  CAS  Google Scholar 

  24. Chen, Q. et al. Nat. Commun. 7, 13193 (2016).

    Article  CAS  Google Scholar 

  25. Kulkarni, A. et al. Proc. Natl Acad. Sci. USA 113, E2104–E2113 (2016).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Shuming Nie.

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Pandit, S., Dutta, D. & Nie, S. Active transcytosis and new opportunities for cancer nanomedicine. Nat. Mater. 19, 478–480 (2020). https://doi.org/10.1038/s41563-020-0672-1

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