Pushing the limit on laminopathies

Mutations in lamins in skeletal muscle cells have been shown to reduce nuclear stability, increase nuclear envelope rupture, and induce DNA damage and cell death. New research shows that limiting mechanical loads can rescue myofibre function and viability.

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Fig. 1: Nuclear envelope rupture during migration of myonuclei along microtubules in the course of differentiation.


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We acknowledge V. Carranco (VCrea) for his contribution to the figure.

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Correspondence to Susana Gonzalo.

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Eissenberg, J.C., Gonzalo, S. Pushing the limit on laminopathies. Nat. Mater. 19, 378–380 (2020).

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