Just dose it

A dose threshold of one trillion nanoparticles in mice has been discovered and is shown to be crucial for overwhelming the nanoparticle uptake kinetics of liver Kupffer cells and for ensuring efficient nanoparticle delivery into solid tumours upon intravenous administration.

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Fig. 1: Nanoparticle number determines tumour delivery and treatment efficacy.


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Correspondence to Twan Lammers.

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Lammers, T. Just dose it. Nat. Mater. 19, 1257–1258 (2020).

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