A dose threshold of one trillion nanoparticles in mice has been discovered and is shown to be crucial for overwhelming the nanoparticle uptake kinetics of liver Kupffer cells and for ensuring efficient nanoparticle delivery into solid tumours upon intravenous administration.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Matsumura, Y. & Maeda, H. Cancer Res. 46, 6387–6392 (1986).
Vidal, L. et al. Clin. Cancer Res. 14, 7127–7137 (2008).
Anchordoquy, T. J. et al. ACS Nano 1, 12–18 (2017).
Shi, J., Kantoff, P. W., Wooster, R. & Farokhzad, O. C. Nat. Rev. Cancer 17, 20–37 (2017).
van der Meel, R. et al. Nat. Nanotechnol. 14, 1007–1017 (2019).
Miller, M. A. et al. Nat. Commun. 6, 8692 (2015).
Miller, M. A. et al. Sci. Transl. Med. 7, 314ra183–314ra183 (2015).
Sindhwani, S. et al. Nat. Mater. 19, 566–575 (2020).
Ouyang, B. et al. Nat. Mater. https://doi.org/10.1038/s41563-020-0755-z (2020).
Wilhelm, S. et al. Nat. Rev. Mater. 1, 16014 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Lammers, T. Just dose it. Nat. Mater. 19, 1257–1258 (2020). https://doi.org/10.1038/s41563-020-00855-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41563-020-00855-7
