CANCER IMMUNOTHERAPY

Dendritic cell tracking and modulation

In situ metabolic labelling and targeted modulation of dendritic cells has been achieved using a hydrogel system in combination with covalent capture of antigens and adjuvants, facilitating improved tumour-specific immune response.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Illustration of the strategy for metabolic labelling of dendritic cells and priming of T cells.

References

  1. 1.

    Oakes, R. S., Froimchuk, E. & Jewell, C. M. Adv. Therapeut. 2, 1800157 (2019).

    Article  Google Scholar 

  2. 2.

    Gosselin, E. A., Eppler, H. B., Bromberg, J. S. & Jewell, C. M. Nat. Mater. 17, 484–498 (2018).

    CAS  Article  Google Scholar 

  3. 3.

    Wang, H. et al. Nat. Mater. https://doi.org/10.1038/s41563-020-0680-1 (2020).

  4. 4.

    Huebsch, N. et al. Proc. Natl Acad. Sci. USA 111, 9762–9767 (2014).

    CAS  Article  Google Scholar 

  5. 5.

    Sharma, P. & Allison, J. P. Cell 161, 205–214 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Alwan, L. M. et al. Target. Oncol. 9, 63–71 (2014).

    Article  Google Scholar 

  7. 7.

    Gammon, J. M., Dold, N. M. & Jewell, C. M. Oncotarget 7, 15421–15443 (2016).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Christopher M. Jewell.

Ethics declarations

Competing statement

C.M.J. is an employee of the Veteran Affairs Maryland Health Care System. The views reported above do not reflect the views of the Department of Veterans Affairs or the United States Government. C.M.J. has an equity position in Cellth Systems, LLC, and Avidea Technologies.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gammon, J.M., Jewell, C.M. Dendritic cell tracking and modulation. Nat. Mater. 19, 1134–1135 (2020). https://doi.org/10.1038/s41563-020-00828-w

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing