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ACUTE KIDNEY INJURY

Enlightening kidney pathophysiology

Nature Materials volume 18, pages 1034–1035 (2019)Cite this article

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Understanding the mechanics of acute kidney injury from toxins, ischemia and sepsis remains challenging. Molecular probes with high renal clearance have now been developed for real-time optical detection of early-stage biomarkers of drug-induced acute kidney injury, and for the understanding of the mechanisms of injury.

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Fig. 1: Molecular renal probes for the detection of drug-induced acute kidney injury.
Fig. 2: The approaches conventially used in drug development for acute kidney injury.

References

  1. Nat. Biotechnol. 28, 431 (2010).

  2. FNIH https://fnih.org/what-we-do/biomarkers-consortium/programs/kidney-safety-biomarkers (2019).

  3. Huang, J., Li, J., Lyu, Y., Miao, Q. & Pu, K. Nat. Mater. https://doi.org/10.1038/s41563-019-0378-4 (2019).

  4. Mattes, W. B. et al. Nat. Biotechnol. 28, 432–433 (2010).

    Article  CAS  Google Scholar 

  5. NIH https://www.niddk.nih.gov/research-funding/research-programs/kidney-precision-medicine-project-kpmp (2019).

  6. Zuk, A. et al. Clin. J. Am. Soc. Nephrol. 13, 1113–1123 (2018).

    Google Scholar 

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Authors and Affiliations

  1. National Institutes of Health, Bethesda, MD, USA

    Stephen M. Hewitt & Robert A. Star

  2. Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA

    Stephen M. Hewitt

  3. Renal Diagnostics and Therapeutics Unit, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA

    Robert A. Star

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  1. Stephen M. Hewitt
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  2. Robert A. Star
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Correspondence to Stephen M. Hewitt.

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Hewitt, S.M., Star, R.A. Enlightening kidney pathophysiology. Nat. Mater. 18, 1034–1035 (2019). https://doi.org/10.1038/s41563-019-0490-5

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  • DOI: https://doi.org/10.1038/s41563-019-0490-5

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