Microparticle debris from prosthetic implants has been shown to induce a type 2 inflammatory response through a Bruton’s tyrosine kinase-dependent signalling pathway.
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de Kouchkovsky, D.A., Ghosh, S. & Rothlin, C.V. Induction of sterile type 2 inflammation. Nature Mater 18, 193–194 (2019). https://doi.org/10.1038/s41563-019-0300-0
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DOI: https://doi.org/10.1038/s41563-019-0300-0