Review Article | Published:

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

Nature Materialsvolume 17pages10631075 (2018) | Download Citation


Mechanical signals are increasingly recognized as overarching regulators of cell behaviour, controlling stemness, organoid biology, tissue development and regeneration. Moreover, aberrant mechanotransduction is a driver of disease, including cancer, fibrosis and cardiovascular defects. A central question remains how cells compute a host of biomechanical signals into meaningful biological behaviours. Biomaterials and microfabrication technologies are essential to address this issue. Here we review a large body of evidence that connects diverse biomaterial-based systems to the functions of YAP/TAZ, two highly related mechanosensitive transcriptional regulators. YAP/TAZ orchestrate the response to a suite of engineered microenviroments, emerging as a universal control system for cells in two and three dimensions, in static or dynamic fashions, over a range of elastic and viscoelastic stimuli, from solid to fluid states. This approach may guide the rational design of technological and material-based platforms with dramatically improved functionalities and inform the generation of new biomaterials for regenerative medicine applications.

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The authors thank all members of the S.P. laboratory for discussion. This work is supported by AIRC Special Program Molecular Clinical Oncology ‘5 per mille’, by an AIRC PI-Grant, by a MIUR-FARE grant to S.P., and by Epigenetics Flagship project CNR-MIUR grants to S.P. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 670126-DENOVOSTEM).

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  1. Department of Industrial Engineering (DII) and INSTM, University of Padua, Padua, Italy

    • Giovanna Brusatin
    •  & Alessandro Gandin
  2. Department of Molecular Medicine (DMM), University of Padua School of Medicine, Padua, Italy

    • Tito Panciera
    • , Alessandro Gandin
    • , Anna Citron
    •  & Stefano Piccolo
  3. IFOM—the FIRC Institute of Molecular Oncology

    • Stefano Piccolo


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All authors contributed equally to all aspects of the article (researching data for article, substantial contribution to discussion of content, writing, review/editing of manuscript before submission).

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