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DEVELOPMENTAL MODELS

Mechanics-guided developmental fate patterning

Nature Materialsvolume 17pages571572 (2018) | Download Citation

A micropatterned human pluripotent stem cell-based developmental model was utilized to demonstrate the role of biophysical cues such as cell size and cytoskeletal contractile forces in directing patterning of neuroepithelial and neural plate border cells.

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Author information

Affiliations

  1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

    • Mukul Tewary
    •  & Peter W. Zandstra
  2. School of Biomedical Engineering, and the Michael Smith Laboratories at the University of British Columbia, Vancouver, British Columbia, Canada

    • Peter W. Zandstra

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Correspondence to Peter W. Zandstra.

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DOI

https://doi.org/10.1038/s41563-018-0121-6