Elucidating potentially causal factors for depression and the direction of their impact could beneficially inform prevention strategies. Mendelian randomization revealed the protective role of increased relative carbohydrate intake in lowering depression risk. In addition, body mass index mediated this effect but to a lesser extent than the total effect size.
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References
Fernstrom, J. D. & Wurtman, R. J. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178, 414–416 (1972). This paper reports that carbohydrate consumption elevates tryptophan and serotonin in the brain.
Burgess, S. et al. Guidelines for performing Mendelian randomization investigations. Wellcome Open Res. 4, 186 (2019). This paper reports guidelines for performing Mendelian randomization analysis.
Meddens, S. F. W. et al. Genomic analysis of diet composition finds novel loci and associations with health and lifestyle. Mol. Psychiatry 26, 2056–2069 (2021). This paper reports genome-wide association studies of diet composition.
Wray, N. R. et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet. 50, 668–681 (2018). This paper reports genome-wide association studies of major depressive disorder.
VanderWeele, T. J. Mediation analysis: a practitioner’s guide. Annu. Rev. Public Health 37, 17–32 (2016). This paper reports guidelines for performing mediation analysis.
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This is a summary of: Yao, S. et al. Bidirectional two-sample Mendelian randomization analysis identifies causal associations between relative carbohydrate intake and depression. Nat. Human Behav. https://doi.org/10.1038/s41562-022-01412-9 (2022).
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The protective effect of relative carbohydrate intake on depression. Nat Hum Behav 6, 1452–1453 (2022). https://doi.org/10.1038/s41562-022-01413-8
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DOI: https://doi.org/10.1038/s41562-022-01413-8
