Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

GENETICS

Selection still shapes our genome

A key question in human evolutionary genetics is whether and how natural selection has shaped the human genome. A new study by Song and colleagues uses GWAS data to examine evidence for the effects of polygenic adaptation in complex traits at different time scales.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Fan, S., Hansen, M. E. B., Lo, Y. & Tishkoff, S. A. Science 354, 54–59 (2016).

    Article  CAS  Google Scholar 

  2. Racimo, F., Sankararaman, S., Nielsen, R. & Huerta-Sánchez, E. Nat. Rev. Genet. 16, 359–371 (2015).

    Article  CAS  Google Scholar 

  3. Song, W. et al. Nat. Hum. Behav. https://doi.org/10.1038/s41562-021-01231-4 (2021).

    Article  PubMed  Google Scholar 

  4. Laland, K. N., Odling-Smee, J. & Myles, S. Nat. Rev. Genet. 11, 137–148 (2010).

    Article  CAS  Google Scholar 

  5. Rinaldi, A. EMBO Rep. 18, 2094–2100 (2017).

    Article  CAS  Google Scholar 

  6. Templeton, A. R. Rambam Maimonides Med. J. 1, e0006 (2010).

    Article  Google Scholar 

  7. Stearns, S. C. & Medzhitov, R. Evolutionary Medicine (Sinauer Associates, 2015).

  8. Barghi, N., Hermisson, J. & Schlötterer, C. Nat. Rev. Genet. 21, 769–781 (2020).

    Article  CAS  Google Scholar 

  9. Field, Y. et al. Science 354, 760–764 (2016).

    Article  CAS  Google Scholar 

  10. Crouch, D. J. M. & Bodmer, W. F. Proc. Natl Acad. Sci. USA 117, 18924–18933 (2020).

    Article  CAS  Google Scholar 

  11. Abdellaoui, A. et al. Nat. Hum. Behav. 3, 1332–1342 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Oscar Lao.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lao, O. Selection still shapes our genome. Nat Hum Behav 5, 1600–1601 (2021). https://doi.org/10.1038/s41562-021-01232-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41562-021-01232-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing