Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Searching for active ingredients to combat youth anxiety and depression

Nature Human Behaviour volume 5, pages 1266–1268 (2021)Cite this article

Subjects

An Author Correction to this article was published on 28 October 2021

This article has been updated

At Wellcome we are committed to finding the next generation of approaches for youth anxiety and depression. Since 2020 we have been learning what works, for whom, and why, by commissioning reviews into the ‘active ingredients’ of successful interventions. Here we share four key calls to action that we hope the mental health science community can take forward.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Change history

References

  1. Whiteford, H. A. et al. Lancet 382, 1575–1586 (2013).

    Article  Google Scholar 

  2. Solmi, M. et al. Mol. Psychiatry (2021).

  3. Embry, D. D. & Biglan, A. Clin. Child Fam. Psychol. Rev. 11, 75–113 (2008).

    Article  Google Scholar 

  4. Leijten, P., Weisz, J. R. & Gardner, F. Clin. Psychol. Sci. 9, 307–322 (2021).

    Article  Google Scholar 

  5. Cuijpers, P., Reijnders, M. & Huibers, M. J. H. Annu. Rev. Clin. Psychol. 15, 207–231 (2019).

    Article  Google Scholar 

  6. Daros, A. R. et al. Nat. Hum. Behav. https://doi.org/10.1038/s41562-021-01191-9 (2021).

  7. Filia, K., Eastwood, O., Herniman, S. & Badcock, P. Transl. Psychiatry 11, 305 (2021).

    Article  Google Scholar 

  8. Krause, K. et al. BMC Psychiatry (in the press).

  9. Bennett, M. P. et al. Transl. Psychiatry 11, 288 (2021).

    Article  Google Scholar 

  10. Lau, J. Y. F. et al. BMC Psychiatry (in the press).

  11. Cohen Kadosh, K. et al. Transl. Psychiatry 11, 352 (2021).

    Article  Google Scholar 

  12. Beames, J. R., Kikas, K. & Werner-Seidler, A. BMC Psychol. (in the press).

  13. The Lancet Psychiatry. Lancet Psychiatry 7, 825 (2020).

  14. Woelbert, E., White, R., Lundell-Smith, K., Grant, J. & Kemmer, D. The Inequities of Mental Health Research (IAMHRF) (2020); https://doi.org/10.6084/m9.figshare.13055897.v2

  15. Cuijpers, P., Stringaris, A. & Wolpert, M. Lancet Psychiatry 7, 925–927 (2020).

    Article  Google Scholar 

Download references

Acknowledgements

We would like to thank all of our active ingredients research teams and lived experience advisors who contributed their expertise to the commission.

Author information

Authors and Affiliations

  1. Wellcome Trust, London, UK

    Catherine L. Sebastian, Inês Pote & Miranda Wolpert

  2. Evidence-based Practice Unit, University College London, London, UK

    Miranda Wolpert

Authors
  1. Catherine L. Sebastian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Inês Pote
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Miranda Wolpert
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Catherine L. Sebastian.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sebastian, C.L., Pote, I. & Wolpert, M. Searching for active ingredients to combat youth anxiety and depression. Nat Hum Behav 5, 1266–1268 (2021). https://doi.org/10.1038/s41562-021-01195-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41562-021-01195-5

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing