Indirect genetic effects, the effects of the genotype of one individual on the phenotype of other individuals, are environmental factors associated with human disease and complex trait variation that could help to expand our understanding of the environment linked to complex traits. Here, we study indirect genetic effects in 80,889 human couples of European ancestry for 105 complex traits. Using a linear mixed model approach, we estimate partner indirect heritability and find evidence of partner heritability on ~50% of the analysed traits. Follow-up analysis suggests that in at least ~25% of these traits, the partner heritability is consistent with the existence of indirect genetic effects including a wide variety of traits such as dietary traits, mental health and disease. This shows that the environment linked to complex traits is partially explained by the genotype of other individuals and motivates the need to find new ways of studying the environment.
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The data that support the results presented in this paper can be accessed from UK Biobank after publication. UK Biobank will link the dataset returned to the publication through their application system.
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This research has been conducted using the UK Biobank Resource under project 788. The work was funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and an MRC grant (MR/P015514/1). A.T. also acknowledges funding from the Medical Research Council Human Genetic Unit and Health Data Research UK (references HDR-9004 and HDR-9003). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Analyses were performed using the ARCHER UK National Supercomputing Service.
The authors declare no competing interests.
Peer review information Nature Human Behaviour thanks Loic Yengo, Piter Bijmaand and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
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Xia, C., Canela-Xandri, O., Rawlik, K. et al. Evidence of horizontal indirect genetic effects in humans. Nat Hum Behav (2020). https://doi.org/10.1038/s41562-020-00991-9