Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Development of reserves over the life course and onset of vulnerability in later life

Abstract

This Review develops a theoretical framework for the development and onset of vulnerability in later life based on the concept of reserves. We stress the advantages of using the concept of reserves in interdisciplinary life-course studies, compared with related concepts such as resources and capital. We enrich the definition of vulnerability as a lack of reserves and a reduced capacity of an individual to restore reserves. Two dimensions of reserves, originating from lifespan psychology and gerontology, are of particular importance: their constitution and sustainability by behaviours and interaction with the environment (the ‘use it or lose it’ paradigm) and the presence of thresholds, below which functioning becomes highly challenging. This heuristic approach reveals the potential for a conceptualization of reserves and is exemplified in an empirical illustration. Further interdisciplinary research based on the concept is needed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1
Fig. 2: Trajectories of verbal fluency and memory recall with aging by education status among Europeans aged 50 years and older (SHARE data).
Fig. 3: Trajectories of disability (ADL, IADL) with aging by job skill status among Europeans aged 50 years and older (SHARE data).

Similar content being viewed by others

References

  1. Baltes, P. B., Staudinger, U. M. & Lindenberger, U. Lifespan psychology: theory and application to intellectual functioning. Annu. Rev. Psychol. 50, 471–507 (1999).

    Article  PubMed  CAS  Google Scholar 

  2. Featherman, D. L. & Lerner, R. M. Ontogenesis and sociogenesis: problematics for theory and research about development and socialization across the lifespan. Am. Sociol. Rev. 50, 659–676 (1985).

    Article  Google Scholar 

  3. Bourdieu, P. in Handbook of Theory and Research for the Sociology of Education (ed. Richardson, J. C.) 241–258 (Greenwood, New York, NY, 1985).

  4. O’Rand, A. M. in Handbook of Aging and the Social Sciences (eds Binstock, H. & George, L. K.) 145–162 (Elsevier, Amsterdam, 2006).

  5. Tan, L. B. Evaluation of cardiac dysfunction, cardiac reserve and inotropic response. Postgrad. Med. J. 67 (Suppl. 1), S10–S20 (1991).

    PubMed  Google Scholar 

  6. Tan, L. B. & Littler, W. A. Measurement of cardiac reserve in cardiogenic shock: implications for prognosis and management. Br. Heart J. 64, 121–128 (1990).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Thomas, D. M., Coles, G. A. & Williams, J. D. What does the renal reserve mean? Kidney Int. 45, 411–416 (1994).

    Article  PubMed  CAS  Google Scholar 

  8. Sharma, A., Mucino, M. J. & Ronco, C. Renal functional reserve and renal recovery after acute kidney injury. Nephron Clin. Pract. 127, 94–100 (2014).

    Article  PubMed  CAS  Google Scholar 

  9. Richardson, M. C., Guo, M., Fauser, B. C. & Macklon, N. S. Environmental and developmental origins of ovarian reserve. Hum. Reprod. Update 20, 353–69 (2014).

    Article  PubMed  CAS  Google Scholar 

  10. Satz, P. Brain reserve capacity on symptom onset after brain injury: a formulation and review of evidence for threshold theory. Neuropsychology 7, 273–295 (1993).

    Article  Google Scholar 

  11. Stern, Y. Cognitive reserve. Neuropsychologia 47, 2015–2028 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Ihle, A. et al. The relation of obesity to performance in verbal abilities, processing speed, and cognitive flexibility in old age: the role of cognitive reserve. Dement. Geriatr. Cogn. Disord. 42, 117–126 (2016).

    Article  PubMed  Google Scholar 

  13. Ihle, A. et al. The association of leisure activities in middle adulthood with cognitive performance in old age: the moderating role of educational level. Gerontology 61, 543–550 (2015).

    Article  PubMed  Google Scholar 

  14. Riley, K. P., Snowdon, D. A., Desrosiers, M. F. & Markesbery, W. R. Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study. Neurobiol. Aging 26, 341–347 (2005).

    Article  PubMed  Google Scholar 

  15. Stern, Y. Cognitive reserve in ageing and Alzheimer’s disease. Lancet Neurol. 11, 1006–1012 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  16. O’Rand, A. M. The precious and the precocious: understanding cumulative disadvantage and cumulative advantage over the life course. Gerontologist 36, 230–238 (1996).

    Article  PubMed  Google Scholar 

  17. Gouldner, A. W. The norm of reciprocity: a preliminary statement. Am. Sociol. Rev. 25, 161–178 (1960).

    Article  Google Scholar 

  18. Kliegel, M. et al. Prospective memory in older adults: where we are now and what is next. Gerontology 62, 459–66 (2016).

    Article  PubMed  Google Scholar 

  19. Gupta, A. et al. Cerebrovascular reserve and stroke risk in patients with carotid stenosis or occlusion: a systematic review and meta-analysis. Stroke 43, 2884–2891 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  20. Antonucci, M. U. et al. Acute preoperative infarcts and poor cerebrovascular reserve are independent risk factors for severe ischemic complications following direct extracranial-intracranial bypass for Moyamoya disease. Am. J. Neuroradiol. 37, 228–235 (2016).

    Article  PubMed  Google Scholar 

  21. Koyanagi, M. et al. Reduced cerebrovascular reserve is associated with an increased risk of postoperative ischemic lesions during carotid artery stenting. J. Neurointerv. Surg. 8, 576–580 (2016).

    Article  PubMed  Google Scholar 

  22. Kuh, D., Karunananthan, S., Bergman, H. & Cooper, R. A life-course approach to healthy ageing: maintaining physical capability. Proc. Nutr. Soc. 73, 237–248 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  23. Ben-Shlomo, Y., Cooper, R. & Kuh, D. The last two decades of life course epidemiology, and its relevance for research on ageing. Int. J. Epidemiol. 45, 973–988 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lopez, M. E. et al. Searching for primary predictors of conversion from mild cognitive impairment to Alzheimer's disease: a multivariate follow-up study. J. Alzheimers Dis. 52, 133–143 (2016).

    Article  PubMed  Google Scholar 

  25. Stern, Y. What is cognitive reserve? Theory and research application of the reserve concept. J. Int. Neuropsychol. Soc. 8, 448–460 (2002).

    Article  PubMed  Google Scholar 

  26. Cirelli, C. Brain plasticity, sleep and aging. Gerontology 58, 441–445 (2012).

    Article  PubMed  Google Scholar 

  27. Greenwood, P. M. Functional plasticity in cognitive aging: review and hypothesis. Neuropsychology 21, 657–673 (2007).

    Article  PubMed  CAS  Google Scholar 

  28. Mora, F., Segovia, G. & del Arco, A. Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res. Rev. 55, 78–88 (2007).

    Article  PubMed  CAS  Google Scholar 

  29. Gross, C. G. Neurogenesis in the adult brain: death of a dogma. Nat. Rev. Neurosci. 1, 67–73 (2000).

    Article  PubMed  CAS  Google Scholar 

  30. Gage, F. H. Neurogenesis in the adult brain. J. Neurosci. 22, 612–613 (2002).

    Article  PubMed  CAS  Google Scholar 

  31. Eriksson, P. S. et al. Neurogenesis in the adult human hippocampus. Nat. Med. 4, 1313–1317 (1998).

    Article  PubMed  CAS  Google Scholar 

  32. Doidge, N. The Brain that Changes Itself. Stories of Personal Triumph from the Frontiers of Brain Science (Penguin Books, London, 2007).

    Google Scholar 

  33. Ingber, A. P. et al. Cerebrospinal fluid biomarkers and reserve variables as predictors of future “non-cognitive” outcomes of Alzheimer’s disease. J. Alzheimers Dis. 52, 1055–1064 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  34. Valenzuela, M. J. & Sachdev, P. Brain reserve and dementia: a systematic review. Psychol. Med. 36, 441–54 (2006).

    Article  PubMed  Google Scholar 

  35. Mortimer, J. A. Brain reserve and the clinical expression of Alzheimeras disease. Geriatrics 52 (Suppl. 2), S50–S53 (1997).

    PubMed  Google Scholar 

  36. Osone, A., Arai, R., Hakamada, R. & Shimoda, K. Cognitive and brain reserve in conversion and reversion in patients with mild cognitive impairment over 12 months of follow-up. J. Clin. Exp. Neuropsychol. 38, 1084–1093 (2016).

    Article  PubMed  Google Scholar 

  37. Valenzuela, M. J. & Sachdev, P. Brain reserve and cognitive decline: a non-parametric systematic review. Psychol. Med. 36, 1065–1073 (2006).

    Article  PubMed  Google Scholar 

  38. Dekhtyar, S., Wang, H.-X., Fratiglioni, L. & Herlitz, A. Childhood school performance, education and occupational complexity: a life-course study of dementia in the Kungsholmen Project. Int. J. Epidemiol. 45, 1207–1215 (2016).

    PubMed  PubMed Central  Google Scholar 

  39. Mondragón, J. D., Celada-Borja, C., Barinagarrementeria-Aldatz, F., Burgos-Jaramillo, M. & Barragán-Campos, H. M. Hippocampal volumetry as a biomarker for dementia in people with low education. Dement. Geriatr. Cogn. Dis. Extra 6, 486–499 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  40. Scarmeas, N., Levy, G., Tang, M. X., Manly, J. & Stern, Y. Influence of leisure activity on the incidence of Alzheimer’s disease. Neurology 57, 2236–2242 (2001).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  41. Weyerman, J. J., Rose, C. & Norton, M. C. Personal journal keeping and linguistic complexity predict late-life dementia risk: The Cache County Journal Pilot Study. J. Gerontol. B. Psychol. Sci. Soc. Sci. 72, 991–995 (2016).

    Google Scholar 

  42. Grotz, C. et al. Why is later age at retirement beneficial for cognition? Results from a French population-based study. J. Nutr. Health Aging 20, 514–519 (2015).

    Article  Google Scholar 

  43. Cheng, S.-T. Cognitive reserve and the prevention of dementia: the role of physical and cognitive activities. Curr. Psychiatry Rep. 18, 85 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  44. Andrejeva, N. et al. Neurocognitive deficits and effects of cognitive reserve in mild cognitive impairment. Dement. Geriatr. Cogn. Disord. 41, 199–209 (2016).

    Article  PubMed  Google Scholar 

  45. Colangeli, S. et al. Cognitive reserve in healthy aging and Alzheimer's disease: a meta-analysis of fMRI studies. Am. J. Alzheimers Dis. Other Demen. 31, 443–449 (2016).

    Article  PubMed  Google Scholar 

  46. Ihle, A., Oris, M., Fagot, D., Maggiori, C. & Kliegel, M. The association of educational attainment, cognitive level of job, and leisure activities during the course of adulthood with cognitive performance in old age: the role of openness to experience. Int. Psychogeriatr. 28, 733–740 (2015).

    Article  PubMed  Google Scholar 

  47. Luerding, R., Gebel, S., Gebel, E. M., Schwab-Malek, S. & Weissert, R. Influence of formal education on cognitive reserve in patients with multiple sclerosis. Front. Neurol. 7, 46 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  48. Milanini, B. et al. Cognitive reserve and neuropsychological functioning in older HIV-infected people. J. Neurovirol. 22, 575–583 (2016).

    Article  PubMed  Google Scholar 

  49. Nunnari, D. et al. Exploring cognitive reserve in multiple sclerosis: new findings from a cross-sectional study. J. Clin. Exp. Neuropsychol. 38, 1158–1167 (2016).

    Article  PubMed  Google Scholar 

  50. Sanchez, J. L., Rodriguez, M. & Carro, J. Influence of cognitive reserve on neuropsychologic functioning in Alzheimer’s disease type sporadic in subjects of Spanish nationality. Neuropsychiatry Neuropsychol. Behav. Neurol. 15, 113–122 (2002).

    PubMed  Google Scholar 

  51. Stern, R. A., Silva, S. G., Chaisson, N. & Evans, D. L. Influence of cognitive reserve on neuropsychological functioning in asymptomatic human immunodeficiency virus-1 infection. Arch. Neurol. 53, 148–153 (1996).

    Article  PubMed  CAS  Google Scholar 

  52. Matura, S. et al. Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial. Transl. Psychiatry 7, e1172 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  53. Estanga, A. et al. Beneficial effect of bilingualism on Alzheimer’s disease CSF biomarkers and cognition. Neurobiol. Aging 50, 144–151 (2016).

    Article  Google Scholar 

  54. Xu, W., Yu, J.-T., Tan, M.-S. & Tan, L. Cognitive reserve and Alzheimer’s disease. Mol. Neurobiol. 51, 187–208 (2015).

    Article  PubMed  CAS  Google Scholar 

  55. Opdebeeck, C., Martyr, A. & Clare, L. Cognitive reserve and cognitive function in healthy older people: a meta-analysis. Aging Neuropsychol. Cogn. 23, 40–60 (2016).

    Article  Google Scholar 

  56. Habeck, C. et al. Cognitive reserve and brain maintenance: orthogonal concepts in theory and practice. Cereb. Cortex 27, 3962–3969 (2016).

    Google Scholar 

  57. Nyberg, L., Lövdén, M., Riklund, K., Lindenberger, U. & Bäckman, L. Memory aging and brain maintenance. Trends Cogn. Sci. 16, 292–305 (2012).

    Article  PubMed  Google Scholar 

  58. Erickson, K. I. et al. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. USA. 108, 3017–3022 (2011).

    Article  PubMed  Google Scholar 

  59. Valenzuela, M. J. et al. Multiple biological pathways link cognitive lifestyle to protection from dementia. Biol. Psychiatry 71, 783–791 (2012).

    Article  PubMed  Google Scholar 

  60. Basso, J. C. & Suzuki, W. A. The effects of acute exercise on mood, cognition, neurophysiology, and neurochemical pathways: a review. Brain Plast. 2, 157–152 (2017).

    Google Scholar 

  61. Kessels, R. P. et al. Effect of formal education on vascular cognitive impairment after stroke: a meta-analysis and study in young-stroke patients. J. Int. Neuropsychol. Soc. 23, 223–238 (2017).

    Article  PubMed  Google Scholar 

  62. Lane, E. M., Paul, R. H., Moser, D. J., Fletcher, T. D. & Cohen, R. A. Influence of education on subcortical hyperintensities and global cognitive status in vascular dementia. J. Int. Neuropsychol. Soc. 17, 531–536 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  63. Guzman-Velez, E. & Tranel, D. Does bilingualism contribute to cognitive reserve? Cognitive and neural perspectives. Neuropsychology 29, 139–150 (2015).

    Article  PubMed  Google Scholar 

  64. Perani, D. & Abutalebi, J. Bilingualism, dementia, cognitive and neural reserve. Curr. Opin. Neurol. 28, 618–25 (2015).

    Article  PubMed  CAS  Google Scholar 

  65. Calvo, N., Garcia, A. M., Manoiloff, L. & Ibanez, A. Bilingualism and cognitive reserve: a critical overview and a plea for methodological innovations. Front. Aging Neurosci. 7, 249 (2015).

    PubMed  Google Scholar 

  66. Verghese, J. et al. Leisure activities and the risk of dementia in the elderly. N. Engl. J. Med. 348, 2508–2516 (2003).

    Article  PubMed  Google Scholar 

  67. Bradley, R. H. & Corwyn, R. F. Socioeconomic status and child development. Annu. Rev. Psychol. 53, 371–399 (2002).

    Article  PubMed  Google Scholar 

  68. Daffner, K. R. Promoting successful cognitive aging: a comprehensive review. J. Alzheimers Dis. 19, 1101–1122 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  69. Lehmann, A. & Skoe, E. Robust encoding in the human auditory brainstem: use it or lose it? Front. Neurosci. 9, 451 (2015).

    PubMed  PubMed Central  Google Scholar 

  70. Wisdom, K. M., Delp, S. L. & Kuhl, E. Use it or lose it: multiscale skeletal muscle adaptation to mechanical stimuli. Biomech. Model. Mechanobiol. 14, 195–215 (2015).

    Article  PubMed  Google Scholar 

  71. Dieckhoff, M. & Gash, V. Unemployed and alone? Unemployment and social participation in Europe. Int. J. Sociol. Soc. Policy 35, 67–90 (2015).

    Article  Google Scholar 

  72. Super, D. E. A life-span, life-space approach to career development. J. Vocat. Behav. 16, 282–298 (1980).

    Article  Google Scholar 

  73. McDonald, S. & Mair, C. A. Social capital across the life course: age and gendered patterns of network resources. Sociol. Forum 25, 335–359 (2010).

    Article  Google Scholar 

  74. Wrzus, C., Hanel, M., Wagner, J. & Neyer, F. J. Social network changes and life events across the life span: a meta-analysis. Psychol. Bull. 139, 53–80 (2013).

    Article  PubMed  Google Scholar 

  75. Widmer, E. Family Configurations: A Structural Approach to Family Diversity (Routledge, London, 2016).

  76. Bidart, C. & Lavenu, D. Evolutions of personal networks and life events. Soc. Netw. 27, 359–376 (2005).

    Article  Google Scholar 

  77. Bryant, C. M. & Conger, R. D. Marital success and domains of social support in long-term relationships: does the influence of network members ever end? J. Marriage Fam. 61, 437–450 (1999).

    Article  Google Scholar 

  78. Kalmijn, M. Shared friendship networks and the life course: an analysis of survey data on married and cohabiting couples. Soc. Netw. 25, 231–249 (2003).

    Article  Google Scholar 

  79. Kalmijn, M. & Broese van Groenou, M. Differential effects of divorce on social integration. J. Soc. Pers. Relat. 22, 455–476 (2005).

    Article  Google Scholar 

  80. Bengtson, V. L., Rosenthal, C. & Burton, L. in Handbook of Aging and the Social Sciences (eds Binstock, R. & George, L.) 253–282 (Academic Press, San Diego, CA, 1995).

  81. Lowenstein, A., Katz, R. & Daatland, S. O. Filial norms and intergenerational support in Europe and Israel: a comparative perspective. Annu. Rev. Gerontol. Geriatr. 24, 200–223 (2004).

    Google Scholar 

  82. Puur, A., Sakkeus, L., Põldma, A. & Herm, A. Intergenerational family constellations in contemporary Europe: evidence from the Generations and Gender Survey. Demogr. Res. S11, 135–172 (2011).

    Article  Google Scholar 

  83. Bengtson, V. L. Beyond the nuclear family: the increasing importance of multigenerational bonds. J. Marriage Fam. 63, 1–16 (2001).

    Article  Google Scholar 

  84. Schnettler, S. & Wöhler, T. in Vielfalt und Zusammenhalt Verhandlungen des 36 Kongresses der Deutschen Gesellschaft für Soziologie in Bochum und Dortmund 2012 1–26 (Campus, Frankfurt/New York, NY, 2014).

  85. Dykstra, P. A. & Hagestad, G. O. Childlessness and parenthood in two centuries. different roads—different maps? J. Fam. Issues 28, 1518–1532 (2007).

    Article  Google Scholar 

  86. Girardin, M. & Widmer, E. D. Lay definitions of family and social capital in later life. Pers. Relat. 22, 712–737 (2015).

    Article  Google Scholar 

  87. De Carlo, I., Aeby, G. & Widmer, E. La variété des configurations familiales après une recomposition: choix et contraintes. Schweiz. Z. Soziol. 40, 9–27 (2014).

    Google Scholar 

  88. Shors, T. J., Anderson, M. L., Curlik, D. M. II & Nokia, M. S. Use it or lose it: how neurogenesis keeps the brain fit for learning. Behav. Brain Res. 227, 450–458 (2012).

    Article  PubMed  CAS  Google Scholar 

  89. Sherman, C. W., Wan, W. H. & Antonucci, T. C. in The Encyclopedia of Adulthood and Aging (ed. Whitbourne, S. K.) 1323–1328 (John Wiley & Sons, 2015).

  90. Naci, H. & Ioannidis, J. P. A. Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study. Br. Med. J. 347, f5577 (2013).

    Article  Google Scholar 

  91. Nexo, M. A., Meng, A. & Borg, V. Can psychosocial work conditions protect against age-related cognitive decline? Results from a systematic review. Occup. Environ. Med. 73, 487–496 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  92. Salthouse, T. A. Mental exercise and mental aging: evaluating the validity of the “use it or lose it” hypothesis. Perspect. Psychol. Sci. 1, 68–87 (2006).

    Article  PubMed  Google Scholar 

  93. Then, F. S. et al. Systematic review of the effect of the psychosocial working environment on cognition and dementia. Occup. Environ. Med. 71, 358–365 (2014).

    Article  PubMed  Google Scholar 

  94. Bialystok, E., Craik, F. I. & Luk, G. Bilingualism: consequences for mind and brain. Trends Cogn. Sci. 16, 240–250 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  95. Molm, L. et al. Building solidarity through generalized exchange: a theory of reciprocity. Am. J. Sociol. 113, 205–242 (2007).

    Article  Google Scholar 

  96. Morgan, D. Rethinking Family Practices (Springer, New York, NY, 2011).

  97. Carstensen, L. L. Selectivity theory: social activity in a life-span context. Annu. Rev. Gerontol. Geriatr. 11, 195–217 (1991).

    Google Scholar 

  98. Spini, D., Bernardi, L. & Oris, M. Toward a life course framework for studying vulnerability. Res. Hum. Dev. 14, 5–25 (2017).

    Article  Google Scholar 

  99. Spini, D., Hanappi, D., Bernardi, L., Oris, M. & Bickel, J.-F. Vulnerability across the life course: a theoretical framework and research directions. LIVES Work. Pap. 2013, 1–35 (2013).

    Google Scholar 

  100. Razurel, C., Bruchon-Schweitzer, M., Dupanloup, A., Irion, O. & Epiney, M. Stressful events, social support and coping strategies of primiparous women during the postpartum period: a qualitative study. Midwifery 27, 237–242 (2011).

    Article  PubMed  CAS  Google Scholar 

  101. Melchiorre, M. G. et al. Social support, socio-economic status, health and abuse among older people in seven European countries. PLoS ONE 8, e54856 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  102. Boker, S. M. Adaptive equilibrium regulation: a balancing act in two timescales. J. Pers. Oriented Res. 1, 99–109 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  103. McCubbin, H. I. & Patterson, J. M. The family stress process. Marriage Fam. Rev. 6, 7–37 (1983).

    Article  Google Scholar 

  104. Karney, B. R. & Bradbury, T. N. The longitudinal course of marital quality and stability: a review of theory, method, and research. Psychol. Bull. 118, 3–34 (1995).

    Article  PubMed  CAS  Google Scholar 

  105. Furstenberg, F. F. & Kaplan, S. B. in Blackwell Companion to the Sociology of Families (eds Richards, M., Scott, J. & Treas, J.) 218–232 (Blackwell, London, 2004).

  106. Kawachi, I. & Berkman, L. F. Social ties and mental health. J. Urban Health 78, 458–467 (2001).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  107. Lin, N., Ye, X. & Ensel, W. M. Social support and depressed mood: a structural analysis. J. Health Soc. Behav. 40, 344–359 (1999).

    Article  PubMed  CAS  Google Scholar 

  108. Song, L., Son, J. & Lin, N. in The Sage Handbook of Social Network Analysis (eds Scott, J. & Carrington, P. J.) 116–128 (Sage, London, 2011).

  109. Jonsson, F., Hammarstrom, A. & Gustafsson, P. E. Social capital across the life course and functional somatic symptoms in mid-adulthood. Scand. J. Public Health 42, 581–588 (2014).

    Article  PubMed  Google Scholar 

  110. Thomas, P. A. Trajectories of social engagement and limitations in late life. J. Health Soc. Behav. 52, 430–43 (2011).

    Article  PubMed  Google Scholar 

  111. Cullati, S., Courvoisier, D. S. & Burton-Jeangros, C. Mental health trajectories and their embeddedness in work and family circumstances: a latent state-trait approach to life-course trajectories. Sociol. Health Illn. 36, 1077–94 (2014).

    Article  PubMed  Google Scholar 

  112. Cullati, S., Rousseaux, E., Gabadinho, A., Courvoisier, D. S. & Burton-Jeangros, C. Factors of change and cumulative factors in self-rated health trajectories: a systematic review. Adv. Life Course Res. 19, 14–27 (2014).

    Article  PubMed  Google Scholar 

  113. Cohen, S. & Wills, T. A. Stress, social support, and the buffering hypothesis. Psychol. Bull. 98, 310–57 (1985).

    Article  PubMed  CAS  Google Scholar 

  114. Kaplan, B. H., Cassel, J. C. & GoreS. Social support and health. Med. Care. 15 (5 Suppl.), 47–58 (1977).

    Article  PubMed  CAS  Google Scholar 

  115. Lin, N., Dean, A. & Ensel, W. M. Social Support, Life Events, and Depression (Academic Press, Orlando, FL, 2013).

  116. Fiorillo, D. Reasons for Unmet needs for Health Care: The Role of Social Capital and Social Support in some Western EU Countries (Parthenope Univ. Naples, Naples, 2017).

    Google Scholar 

  117. Perry, B. L. & Pescosolido, B. A. Social network dynamics and biographical disruption: the case of “first-timers” with mental illness. Am. J. Sociol. 118, 134–175 (2012).

    Article  Google Scholar 

  118. Sapin, M., Widmer, E. D. & Iglesias, K. From support to overload: patterns of positive and negative family relationships of adults with mental illness over time. Soc. Netw. 47, 59–72 (2016).

    Article  Google Scholar 

  119. Bengtson, V. L., Elder, G. H. Jr & Putney, N. M. in The Cambridge Handbook of Age and Ageing (ed. Johnson, M. L.) 493–509 (Cambridge Univ. Press, New York, NY, 2005).

  120. Elder, G. H. Jr The life course as developmental theory. Child Dev. 69, 1–12 (1998).

    Article  PubMed  Google Scholar 

  121. Dannefer, D. Right in front of us: taking everyday life seriously in the study of human development. Res. Hum. Dev. 12, 209–216 (2015).

    Article  Google Scholar 

  122. Levy, R., Ghisletta, P., Le Goff, J.-M., Spini, D. & Widmer, E. (eds) Towards an Interdisciplinary Perspective on the Life Course (Elsevier, Amsterdam, 2005).

  123. Baltes, P. B. On the incomplete architecture of human ontogeny. Selection, optimization, and compensation as foundation of developmental theory. Am. Psychol. 52, 366–80 (1997).

    Article  PubMed  CAS  Google Scholar 

  124. Cicchetti, D. & Rogosch, F. A. Equifinality and multifinality in developmental psychopathology. Dev. Psychopathol. 8, 597–600 (1996).

    Article  Google Scholar 

  125. Raudenbush, S. W. Comparing personal trajectories and drawing causal inferences from longitudinal data. Annu. Rev. Psychol. 52, 501–525 (2001).

    Article  PubMed  CAS  Google Scholar 

  126. Berchtold, A., Surís, J.-C., Meyer, T. & Taushanov, Z. Development of somatic complaints among adolescents and young adults in Switzerland. Swiss J. Sociol. (in the press).

  127. Levy, R. & Widmer, E. (eds) Gendered Life Courses between Individualization and Standardization. A European Approach Applied to Switzerland (LIT Verlag, Wien, 2013).

  128. Dannefer, D. Cumulative advantage/disadvantage and the life course: cross-fertilizing age and social science theory. J. Gerontol. Ser. B 58, 327–337 (2003).

    Article  Google Scholar 

  129. Crystal, S. & Shea, D. Cumulative advantage, cumulative disadvantage, and inequality among elderly people. Gerontologist 30, 437–443 (1990).

    Article  PubMed  CAS  Google Scholar 

  130. Struffolino, E., Studer, M. & Fasang, A. E. Gender, education, and family life courses in East and West Germany: insights from new sequence analysis techniques. Adv. Life Course Res. 29, 66–79 (2016).

    Article  Google Scholar 

  131. Burton-Jeangros, C. & Zimmermann-Sloutskis, D. Life satisfaction trajectories of elderly women living in Switzerland: an age-period-cohort analysis. Ageing Soc. 36, 106–132 (2016).

    Article  Google Scholar 

  132. Sacker, A., Wiggins, R. D. & Bartley, M. Time and place: putting individual health into context. A multilevel analysis of the British household panel survey, 1991–2001. Health Place 12, 279–290 (2006).

    Article  PubMed  Google Scholar 

  133. Sacker, A., Worts, D. & McDonough, P. Social influences on trajectories of self-rated health: evidence from Britain, Germany, Denmark and the USA. J. Epidemiol. Community Health 65, 130–136 (2011).

    Article  PubMed  Google Scholar 

  134. Lewis, M. D. The promise of dynamic systems approaches for an integrated account of human development. Child Dev. 71, 36–43 (2000).

    Article  PubMed  CAS  Google Scholar 

  135. Magnusson, D. in Methods and Models for Studying the Individual (eds Cairns, R. B., Bergman, L. R. & Kagan, J.) 33–64 (Sage Publications, Thousand Oaks, CA, 1998).

  136. Borsch-Supan, A. et al. Data resource profile: the Survey of Health, Ageing and Retirement in Europe (SHARE). Int. J. Epidemiol. 42, 992–1001 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  137. Pichler, F. & Wallace, C. Social capital and social class in Europe: the role of social networks in social stratification. Eur. Sociol. Rev. 25, 319–332 (2009).

    Article  Google Scholar 

  138. Galobardes, B., Shaw, M., Lawlor, D. A., Lynch, J. W. & Davey Smith, G. Indicators of socioeconomic position (part 1). J. Epidemiol. Community Health 60, 7–12 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  139. Galobardes, B., Shaw, M., Lawlor, D. A., Lynch, J. W. & Davey Smith, G. Indicators of socioeconomic position (part 2). J. Epidemiol. Community Health 60, 95–101 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  140. United Nations Educational SaCO. International Standard Classification of Education 1997 (UNESCO, Paris, 1997).

    Google Scholar 

  141. International Labour Office International Standard Classification of Occupations: ISCO-08 (International Labour Office, Geneva, 2012); http://www.ilo.org/wcmsp5/groups/public/---dgreports/---dcomm/---publ/documents/publication/wcms_172572.pdf.

  142. Katz, S., Ford, A. B., Moskowitz, R. W., Jackson, B. A. & Jaffe, M. W. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA 185, 914–919 (1963).

    Article  PubMed  CAS  Google Scholar 

  143. Lawton, M. P. & Brody, E. M. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9, 179–86 (1969).

    Article  PubMed  CAS  Google Scholar 

  144. Haughton, J. & Khandker, S. R. Handbook on Poverty and Inequality (World Bank, Washington DC, 2009); https://openknowledge.worldbank.org/handle/10986/11985

    Google Scholar 

Download references

Acknowledgements

We thank S. Sieber and B. Cheval for data management of the SHARE database. This paper used data from SHARE Waves 1, 2, 3 (SHARELIFE), 4, 5 and 6 (DOIs: 10.6103/SHARE.w1.600, 10.6103/SHARE.w2.600, 10.6103/SHARE.w3.600, 10.6103/SHARE.w4.600, 10.6103/SHARE.w5.600, 10.6103/SHARE.w6.600). The SHARE data collection has been primarily funded by the European Commission through FP5 (QLK6-CT-2001-00360), FP6 (SHARE-I3: RII-CT-2006-062193, COMPARE: CIT5-CT-2005-028857, SHARELIFE: CIT4-CT-2006-028812) and FP7 (SHARE-PREP: N°211909, SHARE-LEAP: N°227822, SHARE M4: N°261982). Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the US National Institute on Aging (U01_AG09740-13S2, P01_AG005842, P01_AG08291, P30_AG12815, R21_AG025169, Y1-AG-4553-01, IAG_BSR06-11, OGHA_04-064, HHSN271201300071C) and from various national funding sources is gratefully acknowledged (see www.share-project.org). This study was supported by the Swiss National Centre of Competence in Research ‘LIVES – Overcoming Vulnerability: Life Course Perspectives’. LIVES is funded by the Swiss National Science Foundation (grant number 51NF40-160590) and jointly hosted by the Universities of Lausanne and Geneva. The authors are grateful to the Swiss National Science Foundation for its financial assistance. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author information

Authors and Affiliations

Authors

Contributions

All authors designed and wrote the paper. Data analysis was conducted by S.C.

Corresponding author

Correspondence to Stéphane Cullati.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cullati, S., Kliegel, M. & Widmer, E. Development of reserves over the life course and onset of vulnerability in later life. Nat Hum Behav 2, 551–558 (2018). https://doi.org/10.1038/s41562-018-0395-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41562-018-0395-3

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing