In response to recommendations to redefine statistical significance to P ≤ 0.005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.
We thank D. Barr, F. Cheung, D. Colquhoun, H. IJzerman, H. Motulsky and R. Morey for helpful discussions while drafting this Comment. D.L. was supported by Nederlandse Organisatie voor Wetenschappelijk Onderzoek 452-17-013. F.G.A. was supported by CONICET. M.A.J.A. was funded by a Biotechnology and Biological Sciences Research Council AFL Fellowship (BB/M013596/1). G.S.C. was supported by the National Institute for Health Research Biomedical Research Centre, Oxford. Z.C. was supported by the Economic and Social Research Council (grant number C106891X). E.S.C. was supported by the European Research Council (ERC-2015-StG-677270). L.D. is supported by the European Research Council (ERC-2014-CoG-647910 KINSHIP). A.-L.v.H. is funded by a Royal Society Dorothy Hodgkin Fellowship (DH150176). M.R.H. was supported by the National Science Foundation under grant SBE SPRF-FR 1714446. J.Lao was supported by the Swiss National Science Foundation grant 100014_156490/1. C.L.d.O. was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico. A.E.M. was supported by the Economic and Social Research Council of the United Kingdom (grant number ES/K009095/1). J.-J.O.d.X. is supported by an internal grant from the KU Leuven (STG/14/054) and by the Fonds voor Wetenschappelijk Onderzoek (1519916N). S.P. was supported by the European Research Council (FP7/2007–2013; ERC grant agreement no. 324176). G.M.A.L. was funded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek 453-14-016. S.G.S. is supported by a Cancer Research UK Fellowship (C42785/A17965). V.S. was supported by the National Institute for Neurological Disorders and Stroke Intramural Research Program (IRP). M.A.V. was supported by grant 2016-T1/SOC-1395 from Comunidad de Madrid. T.Y. was supported by National Institutes of Health award R01MH109682.