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The unfairness of being prosocial

A new study shows that brain responses to unfairness during economic decision-making can predict current and future depression indices. Neural response patterns in the amygdala related to inequity tracked indices of depression, particularly for prosocial individuals who tend to be most self-sacrificing.

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  1. Tanaka, T., Yamamoto, T. & Haruno, M. Nat. Hum. Behav. 1, 0207 (2017).

  2. Drevets, W. C., Price, J. L. & Furey, M. L. Brain Struct. Funct. 213, 93–118 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Gospic, K. et al. PLOS Biol. 9, e1001054 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Haruno, M. & Frith, C. D. Nat. Neurosci. 13, 160–161 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Kendler, K. S., Karkowski, L. M. & Prescott, C. A. Am. J. Psychiatry 156, 837–841 (1999).

    Article  CAS  PubMed  Google Scholar 

  6. Moretti, L. & di Pellegrino, G. Emotion 10, 169–180 (2010).

    Article  PubMed  Google Scholar 

  7. Hewig, J. et al. Psychophysiology 48, 507–514 (2011).

    Article  PubMed  Google Scholar 

  8. Sanfey, A. G., Rilling, J. K., Aronson, J. A., Nystrom, L. E. & Cohen, J. D. Science 300, 1755–1758 (2003).

    Article  CAS  PubMed  Google Scholar 

  9. Knoch, D., Pascual-Leone, A., Meyer, K., Treyer, V. & Fehr, E. Science 314, 829–832 (2006).

    Article  CAS  PubMed  Google Scholar 

  10. Speer, M. E. & Delgado, M. R. Nat. Hum. Behav. 1, 0093 (2017).

    Article  Google Scholar 

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Correspondence to Mauricio R. Delgado.

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The authors declare no competing interests.

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Speer, M.E., Delgado, M.R. The unfairness of being prosocial. Nat Hum Behav 1, 711–712 (2017).

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