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The golden age of computational psychiatry is within sight

Clinically useful tools to identify the aberrant neural circuitry in individuals with psychiatric illness are lacking, as are treatments that do more than just address symptoms. Neuroplasticity-based treatments and computational neuroscience may hold some of the keys to unlocking the golden age of psychiatry.

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  1. 1

    Vinogradov, S., Fisher, M. & de Villers-Sidani, E. Neuropsychopharmacol. Rev. 37, 43–76 (2012).

    Article  Google Scholar 

  2. 2

    Subramaniam, K. et al. Neuron 73, 842–853 (2012).

    CAS  Article  Google Scholar 

  3. 3

    Keshavan, M. S., Vinogradov, S., Rumsey, J., Sherrill, J., Wagner, A. Am. J. Psychiat. 171, 510–522 (2014).

    Article  Google Scholar 

  4. 4

    Williams, L. M. Depress. Anxiety 34, 9–24 (2016).

    Article  Google Scholar 

  5. 5

    Redish, A. D. & Gordon, J. A. (eds) Computational Psychiatry: New Perspectives on Mental Illness (MIT Press, 2016).

    Book  Google Scholar 

  6. 6

    Finn, E. S. et al. Nat. Neurosci. 18, 1664–1671 (2015).

    CAS  Article  Google Scholar 

  7. 7

    Clementz, B. A. et al. Am. J. Psychiat. 173, 373–384 (2016).

    Article  Google Scholar 

  8. 8

    Nienow, T. M., MacDonald, A. W. III & Lim, K. O. Schizophr Res. 172, 218–219 (2016).

    Article  Google Scholar 

  9. 9

    Subramaniam, K. et al. NeuroImage 99, 281–292 (2014).

    Article  Google Scholar 

  10. 10

    Biagianti, B., Fisher, M., Neilands, T. B., Loewy, R. & Vinogradov, S. Neuropsychology 30, 998–1008 (2016).

    Article  Google Scholar 

Download references

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Correspondence to Sophia Vinogradov.

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Competing interests

S.V. is University of Minnesota principal investigator on a Small Business Innovation Research grant awarded by the National Institutes of Mental Health to Posit Science, Inc., a company with a commercial interest in cognitive training software. The University of Minnesota Clinical and Translational Science Institute is one of five collaborators of the sponsor (that is, Posit Science, Inc.). The author is not employed by Posit Science, Inc., does not hold any position within the company, and declares no financial interests in the company.

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Vinogradov, S. The golden age of computational psychiatry is within sight. Nat Hum Behav 1, 0047 (2017).

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