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An apatite for kidney stones

Bruce Fouke explores the biomineralization of calcium oxalate and apatite kidney stones and the opportunities that lie at the intersection of geology, biology and medicine; a transdisciplinary effort traced back some 350 years.

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  1. Winter, J. G. The Prodromus of Nicolaus Steno’s Dissertation Concerning a Solid Body Enclosed by Process of Nature Within a Solid (Macmillan, 1916).

  2. Rosenberg, G. D. Geology 34, 793–796 (2006).

    Article  Google Scholar 

  3. National Research Council. Convergence: Facilitating Transdisciplinary Integration of Life Sciences, Physical Sciences, Engineering, and Beyond (The National Academies Press, 2014).

  4. Sivaguru, M. et al. Nat. Rev. Urol. 18, 404–432 (2021).

    Article  Google Scholar 

  5. Thongprayoon, C., Krambeck, A. E. & Rule, A. D. Nat. Rev. Nephrol. 16, 736–746 (2020).

    Article  Google Scholar 

  6. Khan, S. R., Canales, B. K. & Dominguez-Gutierrez, P. R. Nat. Rev. Nephrol. 17, 417–433 (2021).

    Article  Google Scholar 

  7. Daudon, M. et al. C. R. Chim. 19, 1470–1491 (2016).

    Article  Google Scholar 

  8. Saw, J. J. et al. Kidney360 2, 298–311 (2021).

    Article  Google Scholar 

  9. Sanfort, V. & Bluemke, D. A. Diagn. Interv. Imaging 98, 3–10 (2017).

    Article  Google Scholar 

  10. Humboldt, A. V. Cosmos: A Sketch of a Physical Description of the Universe Vol. I (Henry G. Bohn, 1849).

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Correspondence to Bruce W. Fouke.

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The author declares the following competing interests with research support from Dornier MedTech and Boston Scientific Lumenis. The Carl R. Woese Institute for Genomic Biology is a Carl Zeiss Labs @ Location Partner.

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Fouke, B.W. An apatite for kidney stones. Nat. Geosci. 15, 692–693 (2022).

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