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Antibiotic resistance

Plasmid evolution in the clinic

Plasmids are well known for transferring antibiotic resistance genes between bacteria. A study in the clinic shows that evolutionary dynamics within the gut microbiomes of hospitalized patients lead to rapid adaptive changes, balancing the level of resistance that plasmids provide against the fitness costs that they impose on bacteria.

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Fig. 1: A trade-off governs plasmid evolution in the clinic.

References

  1. Hall, J. P. J., Brockhurst, M. A. & Harrison, E. Philos. Trans. R. Soc. B Biol. Sci. 372, 20160424 (2017).

    Article  Google Scholar 

  2. Brockhurst, M. A. et al. Curr. Biol. 29, R1094–R1103 (2019).

    Article  CAS  PubMed  Google Scholar 

  3. San Millan, A. Trends Microbiol. 26, 978–985 (2018).

    Article  CAS  PubMed  Google Scholar 

  4. San Millan, A. & Maclean, R. C. Microbiol. Spectr. https://doi.org/10.1128/microbiolspec.MTBP-0016-2017 (2019).

    Article  Google Scholar 

  5. Baltrus, D. A. Trends Ecol. Evol. 28, 489–495 (2013).

    Article  PubMed  Google Scholar 

  6. Brockhurst, M. A. & Harrison, E. Trends Microbiol. 30, 534–543 (2022).

    Article  CAS  PubMed  Google Scholar 

  7. Hall, J. P. J. et al. PLoS Biol. https://doi.org/10.1371/journal.pbio.3001225 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Millan, A. S. et al. Nat. Commun. 6, 6845 (2015).

    Article  Google Scholar 

  9. Bottery, M. J., Wood, A. J. & Brockhurst, M. A. Nat. Ecol. Evol. 1, 1364–1369 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  10. DelaFuente, J. Nat. Ecol. Evol. https://doi.org/10.1038/s41559-022-01908-7 (2022).

    Article  PubMed  Google Scholar 

  11. Leon-Sampedro, R. et al. Nat. Microbiol. 6, 606–616 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Michael A. Brockhurst.

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Wright, R.C.T., Brockhurst, M.A. Plasmid evolution in the clinic. Nat Ecol Evol 6, 1806–1807 (2022). https://doi.org/10.1038/s41559-022-01907-8

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