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EVOLUTION

Neuropeptides at the origin of neurons

Cnidarians and ctenophores have morphologically simpler nervous systems than those of bilaterians. Discovery and characterization of neuropeptides in a comb jelly and a sea anemone support a common origin of animal peptidergic neurons from digestive cells that could sense their environment.

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Fig. 1: Illustration of the digestive neuron hypothesis proposed by Hayakawa et al.

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Correspondence to Maria Y. Sachkova.

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Sachkova, M.Y. Neuropeptides at the origin of neurons. Nat Ecol Evol 6, 1410–1411 (2022). https://doi.org/10.1038/s41559-022-01828-6

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