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Spatial models of tumour evolution

Nature Ecology & Evolution volume 6, pages 26–27 (2022)Cite this article

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Spatiotemporal modelling of tumours detects at least two distinct models of cancer evolution and reveals the influence of necrosis in enhancing the metastatic potential in both models.

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Fig. 1: Models of fitness acquisition in human tumours.

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Authors and Affiliations

  1. Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA

    Dakim K. Gaines

  2. Vanderbilt-Ingram Cancer Center, Nashville, TN, USA

    Dakim K. Gaines & W. Kimryn Rathmell

  3. Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    W. Kimryn Rathmell

Authors
  1. Dakim K. Gaines
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  2. W. Kimryn Rathmell
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Corresponding author

Correspondence to W. Kimryn Rathmell.

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Competing interests

W.K.R. has received research support from Incyte Corp and her spouse is a founder, scientific advisory board member and stockholder of Sitryx Therapeutics, a scientific advisory board member and stockholder of Caribou Biosciences, a member of the scientific advisory board of Nirogy Therapeutics, has consulted for Merck, Pfizer and Mitobridge within the past three years, and has received research support from Incyte Corp., Calithera Biosciences and Tempest Therapeutics. D.K.G. declares no competing interests.

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Gaines, D.K., Rathmell, W.K. Spatial models of tumour evolution. Nat Ecol Evol 6, 26–27 (2022). https://doi.org/10.1038/s41559-021-01584-z

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