Fig. 3: Two methods for building transmissible vaccines. | Nature Ecology & Evolution

Fig. 3: Two methods for building transmissible vaccines.

From: Self-disseminating vaccines to suppress zoonoses

Fig. 3

Katy Riendeau

a, Attenuation is used to reduce the virulence of the wild-type pathogen. Attenuation is shown here as the gradual accumulation of point mutations (blue). b, Recombination is used to insert an immunogenic region of the pathogen genome (red) into the genome of an innocuous but transmissible viral vector (yellow).

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