Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Resistance games

A game theory study supported by in vitro experimental data shows that drug treatment of non-small-cell lung cancer cells causes the cells to switch between evolutionary games they play among each other. Moreover, the work calls into question standard assumptions on the fitness costs of drug resistance to cancer cells.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1


  1. Von Neumann, J. & Morgenstern, O. Theory of Games and Economic Behavior 3rd edn (Princeton Univ. Press, Princeton, NJ, USA, 1953).

  2. Maynard Smith, J. & Price, G. R. Nature 246, 15–18 (1973).

    Article  Google Scholar 

  3. Brown, J. S. Proc R. Soc. B 283, 20160847 (2016).

    Article  Google Scholar 

  4. Tomlinson, I. P. Eur. J. Cancer 33, 1495–1500 (1997).

    CAS  Article  Google Scholar 

  5. Gatenby, R. A. & Vincent, T. L. Cancer Res. 63, 6212–6220 (2003).

    CAS  PubMed  Google Scholar 

  6. Basanta, D., Gatenby, R. A. & Anderson, A. R. Mol. Pharm. 9, 914–921 (2012).

    CAS  Article  Google Scholar 

  7. Zhang, J., Cunningham, J. J., Brown, J. S. & Gatenby, R. A. Nat. Commun. 8, 1816 (2017).

    Article  Google Scholar 

  8. Gatenby, R. A. Nature 459, 508–509 (2009).

    CAS  Article  Google Scholar 

  9. Staňková, K., Brown, J. S., Dalton, W. S. & Gatenby, R. A. JAMA Oncol. (2018).

    Article  Google Scholar 

  10. Kaznatchev, A., Peacock, J., Basanta, D., Marusyk, A. & Scott, J. G. Nat. Ecol. Evol. (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Kateřina Staňková.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Staňková, K. Resistance games. Nat Ecol Evol 3, 336–337 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing