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Virology

Influenza evolution with little host selection

Influenza viruses undergo rapid antigenic evolution. Analysis of a large dataset of influenza virus sequences, using host age as a proxy for immune experience, shows no evidence for immune positive selection driving antigenic evolution in individual infected humans.

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References

  1. Rolfes, M. A. et al. Estimated Influenza Illnesses, Medical Visits, Hospitalizations, and Deaths Averted by Vaccination in the United States (Centers for Disease Control and Prevention, 2016).

  2. Han, A. X., Maurer-Stroh, S. & Russell, C. A. Nat. Ecol. Evol. https://doi.org/10.1038/s41559-018-0741-x (2018).

  3. Koel, B. F. et al. Science 342, 976–979 (2013).

    Article  CAS  Google Scholar 

  4. Rambaut, A. et al. Nature 453, 615–619 (2008).

    Article  CAS  Google Scholar 

  5. Bedford, T. et al. Nature 523, 217–220 (2015).

    Article  CAS  Google Scholar 

  6. Dinis, J. M. et al. J. Virol. 90, 3355–3365 (2016).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Debbink, K. et al. PLoS Pathog. 13, e1006194 (2017).

    Article  Google Scholar 

  8. Hensley, S. E. et al. Science 326, 734–736 (2009).

    Article  CAS  Google Scholar 

  9. McCrone, J. T. et al. eLife 7, e35962 (2018).

    PubMed  PubMed Central  Google Scholar 

  10. Xue, K. S. et al. eLife 6, e26875 (2017).

    Article  Google Scholar 

  11. Davis, A. K. F. et al. J. Virol. 92, e00859-18 (2018).

    Article  Google Scholar 

Download references

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Correspondence to Thomas C. Friedrich.

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Braun, K.M., Friedrich, T.C. Influenza evolution with little host selection. Nat Ecol Evol 3, 159–160 (2019). https://doi.org/10.1038/s41559-018-0782-1

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