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Redundant regulation

Control of gene activity through transcriptional regulatory elements is a major driving force in human evolution. A new study measures nascent transcription directly and shows that sequence, activity and three-dimensional organization of transcriptional regulatory elements all contribute to the evolution of gene activity within primate CD4+ T cells.

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Fig. 1: PRO-Seq signal identifies TREs and quantifies transcription activity directly.


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Correspondence to Scott A. Lacadie or Uwe Ohler.

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The authors declare no competing financial interests.

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Lacadie, S.A., Ohler, U. Redundant regulation. Nat Ecol Evol 2, 418–419 (2018).

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