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GENE EXPRESSION

Redundant regulation

Nature Ecology & Evolutionvolume 2pages418419 (2018) | Download Citation

Control of gene activity through transcriptional regulatory elements is a major driving force in human evolution. A new study measures nascent transcription directly and shows that sequence, activity and three-dimensional organization of transcriptional regulatory elements all contribute to the evolution of gene activity within primate CD4+ T cells.

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Author information

Affiliations

  1. Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, 13125, Berlin, Germany

    • Scott A. Lacadie
    •  & Uwe Ohler
  2. Berlin Institute of Health (BIH), 10178, Berlin, Germany

    • Scott A. Lacadie
    •  & Uwe Ohler
  3. Department of Biology, Humboldt Universitaet zu Berlin, 10115, Berlin, Germany

    • Uwe Ohler

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Scott A. Lacadie or Uwe Ohler.

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DOI

https://doi.org/10.1038/s41559-018-0479-5

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