Control of gene activity through transcriptional regulatory elements is a major driving force in human evolution. A new study measures nascent transcription directly and shows that sequence, activity and three-dimensional organization of transcriptional regulatory elements all contribute to the evolution of gene activity within primate CD4+ T cells.
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Lacadie, S.A., Ohler, U. Redundant regulation. Nat Ecol Evol 2, 418–419 (2018). https://doi.org/10.1038/s41559-018-0479-5
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DOI: https://doi.org/10.1038/s41559-018-0479-5