IMMUNE EVOLUTION

Sick if you do, sick if you don’t

The immune system must distinguish self from non-self, but an imbalanced reaction in either direction can lead to immunopathology or severe infection. A new model incorporating host life history predicts which error will be more tolerated.

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Fig. 1: Discrimination involves a tradeoff between two types of error.

References

  1. 1.

    Metcalf, C. J. E., Tate, A. T. & Graham, A. L. Nat. Ecol. Evol. https://doi.org/10.1038/s41559-017-0315-3 (2017).

  2. 2.

    Wardemann, H. et al. Science 301, 1374–1377 (2003).

    CAS  Article  Google Scholar 

  3. 3.

    Scalapino, K. J. & Daikh, D. I. Immunol. Rev. 223, 143–155 (2008).

    CAS  Article  Google Scholar 

  4. 4.

    Duffy, L. & O’Reilly, S. C. ImmunoTargets Ther. 5, 69–80 (2016).

    CAS  Article  Google Scholar 

  5. 5.

    Boots, M. et al. Parasite Immunol. 35, 331–338 (2013).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Mayer, A. et al. Proc. Natl Acad. Sci. USA 113, 8630–8635 (2016).

    CAS  Article  Google Scholar 

  7. 7.

    Simon, A. K. et al. Proc. R. Soc. B 282, 20143085 (2015).

    Article  Google Scholar 

  8. 8.

    Brodin, P. & Davis, M. M. Nat. Rev. Immunol. 17, 21–29 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Gruver, A. L. et al. J. Pathol. 211, 144–156 (2007).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Sarah Cobey.

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Cobey, S. Sick if you do, sick if you don’t. Nat Ecol Evol 1, 1602–1603 (2017). https://doi.org/10.1038/s41559-017-0342-0

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