Sick if you do, sick if you don’t

The immune system must distinguish self from non-self, but an imbalanced reaction in either direction can lead to immunopathology or severe infection. A new model incorporating host life history predicts which error will be more tolerated.

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Fig. 1: Discrimination involves a tradeoff between two types of error.


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Correspondence to Sarah Cobey.

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Cobey, S. Sick if you do, sick if you don’t. Nat Ecol Evol 1, 1602–1603 (2017).

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