Figure 1 : Illustration demonstrating fNM potential compensation and possible adaptation in a protein-coding gene.

From: The genomic landscape of evolutionary convergence in mammals, birds and reptiles

Figure 1

a, A phylogenetic tree indicating the locations where a representative fNM, S155T, in the PDB structure 3AG3 chain B (the mtDNA encoded COX2) have independently re-occurred (marked as red triangle), as well as compensatory co-occurring mutations (indicated in additional colours). b, Three-dimensional structures of the mtDNA-encoded COX2 (PDB ID 3AG3 chain B), indicating the locations of the functional nodal mutation S155T, as well as co-occurring compensatory mutations. Functional nodal mutations are indicated by triangles; less-functional nodal mutations are indicated by squares.