In molecular biology, few molecules have had as profound an impact as Cas9. Madeleine King, Kayla Perry, Mitchell McAndrew and Audrone Lapinaite discuss how this multifunctional molecular tool of genetic engineering is revolutionizing multiple fields.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ishino, Y., Shinagawa, H., Makino, K., Amemura, M. & Nakata, A. J. Bacteriol. 169, 5429–5433 (1987).
Marraffini, L. & Sontheimer, E. Nat. Rev. Genet. 11, 181–190 (2010).
Mojica, F. J. et al. J. Mol. Evol. 60, 174–182 (2005).
Jinek, M. et al. Science 337, 816–821 (2012).
Xue, C. & Greene, E. C. Trends Genet. 37, 639–656 (2021).
Liu, G., Lin, Q., Jin, S. & Gao, C. Mol. Cell 82, 333–347 (2022).
Mali, P. et al. Science 339, 823–826 (2013).
Jinek, M. et al. Elife 2, e00471 (2013).
Liu, Q. et al. Int. J. Mol. Sci. 22, 4206 (2021).
Frangoul, H. et al. NEJM 384, 252–260 (2021).
Chiesa, R. et al. NEJM 389, 899–910 (2023).
US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/study/NCT05398029 (2023).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
King, M.B., Perry, K.N., McAndrew, M.J. et al. The genetic engineering Swiss army knife. Nat. Chem. 16, 1034 (2024). https://doi.org/10.1038/s41557-024-01544-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-024-01544-7
