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Synthetic methodology

Cyclopropenium functionalization

Although functionalized cyclopropenes have found uses in many applications, their synthesis has been severely limited. Now, a hypervalent iodine reagent, in conjunction with gold catalysis, has been utilized to control their reactivity, allowing efficient formation of cyclopropenyl alkynes/alkenes.

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Fig. 1: Production of alkynyl/alkenyl cyclopropenes using hypervalent iodine reagents CpBX and gold catalysis.

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Correspondence to Berit Olofsson.

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Doobary, S., Olofsson, B. Cyclopropenium functionalization. Nat. Chem. 16, 847–848 (2024). https://doi.org/10.1038/s41557-024-01541-w

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