Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Homogenous catalysis

Hydrogenative double-bond deuteration

Deuterated compounds are used in many applications such as mass-spectrometry standards, drugs or in organic light-emitting diodes. Now, hydrogen-activated homogeneous pincer complex catalysts can be used to perform selective alkene deuteration with the cheapest available deuterium source, D2O.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Fig. 1: An overview of the hydrogenative perdeuteration of double bonds.


  1. Atzrodt, J., Derdau, V., Reid, M. & Kerr, W. J. Angew. Chem. Int. Ed. 57, 1758–1784 (2018).

    Article  CAS  Google Scholar 

  2. Luo, J., Lu, L., Montag, M., Liang, Y. & Milstein, D. Nat. Chem. (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Voges, R., Heys, R. & Moenius, T. Preparation of Compounds labeled with Tritium and Carbon‐14 (Wiley, 2009).

  4. Sawama, Y., Monguchi, Y. & Sajiki, H. Synlett 23, 959–972 (2012).

    Article  CAS  Google Scholar 

  5. Kopf, S. et al. Chem. Rev. 122, 6634–6718 (2022).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Volker Derdau.

Ethics declarations

Competing interests

The authors are employed at Sanofi and hold stocks and shares of the company.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tarasewicz, A., Derdau, V. Hydrogenative double-bond deuteration. Nat. Chem. 15, 1332–1333 (2023).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing