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Synthetic methodology

Aryl ortho methoxylation

Aryl ethers are useful intermediates in organic synthesis and are found in countless biologically active compounds. Now, through palladium/norbornene cooperative catalysis and incorporation of a polarity-reversed N–O reagent as the O-electrophile, an efficient arene methoxylation approach has been successfully developed.

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Fig. 1: Alkyl aryl ethers and their preparations.


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Correspondence to Zhenhua Gu.

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Zhao, K., Gu, Z. Aryl ortho methoxylation. Nat. Chem. 15, 1334–1335 (2023).

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