Challenges in the synthesis of heparan sulfate (HS) glycosaminoglycans have limited access to defined HS oligosaccharides bearing a diverse array of sulfation sequences. A concise, divergent synthetic approach now provides a library of 64 HS tetrasaccharides displaying a comprehensive set of sulfation sequences, offering insight into the elusive sulfation code of glycosaminoglycans.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Vallet, S. D., Berthollier, C. & Ricard-Blum, S. The glycosaminoglycan interactome 2.0. Am. J. Physiol. Cell Physiol. 322, C1271–C1278 (2022). A review article that presents current understanding of the glycosaminoglycan interactome and discusses the protein pathway involvement, along with the relevance of the interactome to human health and disease.
Xu, D. & Esko, J. D. Demystifying heparan sulfate–protein interactions. Annu. Rev. Biochem. 83, 129–157 (2014). A review article that provides biochemical, structural and functional insights into HS–protein interactions.
Pawar, N. J. et al. Expedient synthesis of core disaccharide building blocks from natural polysaccharides for heparan sulfate oligosaccharide assembly. Angew. Chem. Int. Ed. 58, 18577–18583 (2019). This article presents a strategy for generating key disaccharide intermediates from natural heparin.
Kim, Y., Hyun, J. Y. & Shin, I. Glycan microarrays from construction to applications. Chem. Soc. Rev. 51, 8276–8299 (2022). A review article that presents an overview of glycan microarray technology.
Panza, M., Pistorio, S. G., Stine, K. J. & Demchenko, A. V. Automated chemical oligosaccharide synthesis: novel approach to traditional challenges. Chem. Rev. 118, 8105–8150 (2018). A review article that discusses advances in automated oligosaccharide synthesis.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Wang, L. et al. Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan–protein interactions Nat. Chem. https://doi.org/10.1038/s41557-023-01248-4 (2023).
Rights and permissions
About this article
Cite this article
Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence space. Nat. Chem. 15, 1062–1063 (2023). https://doi.org/10.1038/s41557-023-01270-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-023-01270-6
