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Metal-based drugs

Anticancer platinum-based photo-oxidants in a new light

Pharmacologically inactive prodrugs that can be activated by near-infrared light are attractive candidates for clinical applications. Now, platinum-based photo-oxidants have been shown to eradicate tumours in mice with a new mode of action.

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Fig. 1: Schematic illustration of platinum(iv)-based photo-oxidants for inducing nonconventional necrosis upon NIR photoactivation.

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Correspondence to Gilles Gasser.

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Vigueras, G., Gasser, G. Anticancer platinum-based photo-oxidants in a new light. Nat. Chem. 15, 896–898 (2023). https://doi.org/10.1038/s41557-023-01250-w

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