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Non-covalent synthesis

Site selectivity steps in

The concepts of multistep processes and regioselectivity — fundamental in covalent synthesis — have now been applied to the non-covalent synthesis of sequence-controlled multiblock supramolecular polymers.

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Fig. 1: Multistep non-covalent synthesis of supramolecular concentric toroids.


  1. Lehn, J.-M. Supramolecular Chemistry: Concepts and Perspectives (Wiley, 1995).

  2. Whitesides, G. M. & Grzybowski, B. Science 295, 2418–2421 (2002).

    Article  CAS  PubMed  Google Scholar 

  3. Vantomme, G. & Meijer, E. W. Science 363, 1396–1397 (2019).

    Article  CAS  PubMed  Google Scholar 

  4. Baran, P. S. J. Am. Chem. Soc. 140, 4751–4755 (2018).

    Article  CAS  PubMed  Google Scholar 

  5. Sasaki, N. et al. Nat. Chem. (2023).

    Article  PubMed  Google Scholar 

  6. Sasaki, N. et al. Nat. Commun. 11, 3578 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Vonk, K. M., Meijer, E. W. & Vantomme, G. Chem. Sci. 12, 13572–13579 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hassner, A. J. Org. Chem. 33, 2684–2686 (1968).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Ghislaine Vantomme.

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Vantomme, G. Site selectivity steps in. Nat. Chem. 15, 894–895 (2023).

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